Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

L. Feller; J. P. Bearinger; L. Wu; J. A. Hubbell; M. Textor; S. Tosatti

doi:10.1016/j.susc.2008.05.010

Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

L. Feller, J. P. Bearinger, L. Wu, J. A. Hubbell, M. Textor, S. Tosatti

Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93% on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.

Original language	English (US)
Pages (from-to)	2305-2310
Number of pages	6
Journal	Surface Science
Volume	602
Issue number	13
DOIs	https://doi.org/10.1016/j.susc.2008.05.010
State	Published - Jul 1 2008

Keywords

Adsorption
Biosensing
Gold
Patterning
Photolithography
Self-assembly
Surface plasmon techniques
ToF-SIMS

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Condensed Matter Physics
Surfaces and Interfaces

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Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique. / Feller, L.; Bearinger, J. P.; Wu, L.; Hubbell, J. A.; Textor, M.; Tosatti, S.

In: Surface Science, Vol. 602, No. 13, 01.07.2008, p. 2305-2310.

Research output: Contribution to journal › Article › peer-review

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title = "Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique",

abstract = "Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93% on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.",

keywords = "Adsorption, Biosensing, Gold, Patterning, Photolithography, Self-assembly, Surface plasmon techniques, ToF-SIMS",

author = "L. Feller and Bearinger, {J. P.} and L. Wu and Hubbell, {J. A.} and M. Textor and S. Tosatti",

note = "Funding Information: We thank Tobias K{\"u}nzler and Brigitte St{\"a}dler for assistance with the light microscopy images, and Thomas Bl{\"a}ttler and Christoph Huwiler for support with the photolithographic process. The FIRST team and especially Maria Leibinger are acknowledged for access to clean room conditions and support. Thanks to Didier Falconnet for assistance with the MAPL process. Whitney Hartung and Sara Morgenthaler aided the AFM measurements. We gratefully acknowledge funding from NIH R21 EB003991. This work was partially performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract W-7405-Eng-48 and under Contract DE-AC52-07NA27344. ",

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T1 - Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

AU - Feller, L.

AU - Bearinger, J. P.

AU - Wu, L.

AU - Hubbell, J. A.

AU - Textor, M.

AU - Tosatti, S.

N1 - Funding Information: We thank Tobias Künzler and Brigitte Städler for assistance with the light microscopy images, and Thomas Blättler and Christoph Huwiler for support with the photolithographic process. The FIRST team and especially Maria Leibinger are acknowledged for access to clean room conditions and support. Thanks to Didier Falconnet for assistance with the MAPL process. Whitney Hartung and Sara Morgenthaler aided the AFM measurements. We gratefully acknowledge funding from NIH R21 EB003991. This work was partially performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract W-7405-Eng-48 and under Contract DE-AC52-07NA27344.

PY - 2008/7/1

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N2 - Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93% on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.

AB - Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93% on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.

KW - Adsorption

KW - Biosensing

KW - Gold

KW - Patterning

KW - Photolithography

KW - Self-assembly

KW - Surface plasmon techniques

KW - ToF-SIMS

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