Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

L. Feller, J. P. Bearinger, L. Wu, J. A. Hubbell, M. Textor, S. Tosatti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93% on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.

Original languageEnglish
Pages (from-to)2305-2310
Number of pages6
JournalSurface Science
Volume602
Issue number13
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

Fingerprint

Ethylene Glycol
Ethylene glycol
polypropylene
Passivation
Gold
Polyethylene glycols
passivity
sulfides
glycols
Polypropylenes
ethylene
assembly
gold
Substrates
block copolymers
proteins
serums
adsorption
Proteins
Adsorption

Keywords

  • Adsorption
  • Biosensing
  • Gold
  • Patterning
  • Photolithography
  • Self-assembly
  • Surface plasmon techniques
  • ToF-SIMS

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces

Cite this

Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique. / Feller, L.; Bearinger, J. P.; Wu, L.; Hubbell, J. A.; Textor, M.; Tosatti, S.

In: Surface Science, Vol. 602, No. 13, 01.07.2008, p. 2305-2310.

Research output: Contribution to journalArticle

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abstract = "Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropriate architecture is chosen. The established molecular-assembly patterning by lift-off (MAPL) technique can convert a prestructured resist film into a pattern of biointeractive chemistry and a non-interactive background. Employing the MAPL technique, we produced a micron-scale PPS-PEG pattern on a gold substrate, and then characterized the patterned structure with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Subsequent exposure of the PPS-PEG/gold pattern to protein adsorption (full human serum) was monitored in situ; SPR-imaging (i-SPR) shows a selective adsorption of proteins on gold, but not on PPS-PEG areas. Analysis shows a reduction of serum adsorption up to 93{\%} on the PPS-PEG areas as compared to gold, in good agreement with previous analysis of homogenously adsorbed PPS-PEG on gold. MAPL patterning of PPS-PEG block copolymers is straightforward, versatile and reproducible, and may be incorporated into biosensor-based surface analysis methods.",
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