Microparticles in stored red blood cells as potential mediators of transfusion complications

Wenche Jy, Marco Ricci, Sherry Shariatmadar, Orlando W Gomez-Marin, Lawrence H. Horstman, Yeon Ahn

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

This article reviews evidence for the involvement of cell-derived microparticles (MPs) in transfusion-related adverse events. The controversy concerning possible added risk of older versus fresher stored blood is also reviewed and is consistent with the hypothesis that MPs are involved with adverse events. Although all types of circulating MPs are discussed, the emphasis is on red blood cell-derived MPs (RMPs). The evidence is particularly strong for involvement of RMPs in transfusion-related acute lung injury, but also for postoperative thrombosis. However, this evidence is largely circumstantial. Work in progress to directly test the hypothesis is also briefly reviewed.

Original languageEnglish
Pages (from-to)886-893
Number of pages8
JournalTransfusion
Volume51
Issue number4
DOIs
StatePublished - Apr 1 2011

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Cell-Derived Microparticles
Erythrocytes
Acute Lung Injury
Thrombosis

ASJC Scopus subject areas

  • Hematology
  • Immunology
  • Immunology and Allergy

Cite this

Jy, W., Ricci, M., Shariatmadar, S., Gomez-Marin, O. W., Horstman, L. H., & Ahn, Y. (2011). Microparticles in stored red blood cells as potential mediators of transfusion complications. Transfusion, 51(4), 886-893. https://doi.org/10.1111/j.1537-2995.2011.03099.x

Microparticles in stored red blood cells as potential mediators of transfusion complications. / Jy, Wenche; Ricci, Marco; Shariatmadar, Sherry; Gomez-Marin, Orlando W; Horstman, Lawrence H.; Ahn, Yeon.

In: Transfusion, Vol. 51, No. 4, 01.04.2011, p. 886-893.

Research output: Contribution to journalArticle

Jy, W, Ricci, M, Shariatmadar, S, Gomez-Marin, OW, Horstman, LH & Ahn, Y 2011, 'Microparticles in stored red blood cells as potential mediators of transfusion complications', Transfusion, vol. 51, no. 4, pp. 886-893. https://doi.org/10.1111/j.1537-2995.2011.03099.x
Jy, Wenche ; Ricci, Marco ; Shariatmadar, Sherry ; Gomez-Marin, Orlando W ; Horstman, Lawrence H. ; Ahn, Yeon. / Microparticles in stored red blood cells as potential mediators of transfusion complications. In: Transfusion. 2011 ; Vol. 51, No. 4. pp. 886-893.
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