Microparticle size and its relation to composition, functional activity, and clinical significance

Wenche Jy, Lawrence L. Horstman, Yeon S. Ahn

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

It is emerging that cell-derived microparticles (MP) have multiple functional activities in areas including hemostasis, thrombosis, inflammation, and as messengers in the transport of bioactive lipids, cytokines, complement, and immune signaling. Some of these activities may be performed by distinct phenotypic subsets of MP, even if derived from the same cell type. The focus of this article concerns the size classes of MP, covering methods of MP size measurement, differences in composition between size classes, and relation of size to functional (procoagulant) activity. Some of the issues considered remain to be resolved, such as whether the MP known as exosomes are truly a distinct class of MP, as well as the detailed mechanisms underlying the release of MP of different size ranges.

Original languageEnglish (US)
Pages (from-to)876-880
Number of pages5
JournalSeminars in Thrombosis and Hemostasis
Volume36
Issue number8
DOIs
StatePublished - 2010

Keywords

  • exosomes
  • microparticles
  • nanoparticles
  • Size analysis

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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