TY - JOUR
T1 - Micronutrients and HIV-1 disease progression
AU - Baum, Marianna K.
AU - Shor-Posner, Gail
AU - Lu, Ying
AU - Rosner, Bernard
AU - Sauberlich, Howerde E.
AU - Fletcher, Mary Ann
AU - Szapocznik, Jose
AU - Eisdorfer, Carl
AU - Buring, Julie E.
AU - Hennekens, Charles H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995/9
Y1 - 1995/9
N2 - Objective: To determine whether nutritional status affects immunological markers of HIV-1 disease progression. Design: A longitudinal study, to evaluate the relationship between plasma levels of nutrients and CD4 cell counts, along and in combination with β2-microglobulin (β2M; AIDS index) over an 18-month follow-up. Methods: Biochemical measurements of nutritional status including plasma proteins, zinc, iron and vitamins B1, B2, B6, B12 (cobalamin), A, E, C and folate and immunological markers [lymphocyte subpopulations (CD4) and β2M] were obtained in 108 HIV-1-seropositive homosexual men at baseline and over three 6-month time periods. Changes in nutrient status (e.g., normal to deficient, deficient to normal), were compared with immunological parameters in the same time periods using an autoregressive model. Results: Development of deficiency of vitamin A or vitamin B12 was associated with a decline in CD4 cell count (P = 0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B12 and zinc was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and 0.0112, respectively). These findings were largely unaffected by zidovudine use. For vitamin B12, low baseline status significantly predicted accelerated HIV-1 disease progression determined by CD4 cell count (P = 0.041) and the AIDS index (P = 0.005). Conclusions: These data suggest that micronutrient deficiencies are associated with HIV-1 disease progression and raise the possibility that normalization might increase symptom-free survival.
AB - Objective: To determine whether nutritional status affects immunological markers of HIV-1 disease progression. Design: A longitudinal study, to evaluate the relationship between plasma levels of nutrients and CD4 cell counts, along and in combination with β2-microglobulin (β2M; AIDS index) over an 18-month follow-up. Methods: Biochemical measurements of nutritional status including plasma proteins, zinc, iron and vitamins B1, B2, B6, B12 (cobalamin), A, E, C and folate and immunological markers [lymphocyte subpopulations (CD4) and β2M] were obtained in 108 HIV-1-seropositive homosexual men at baseline and over three 6-month time periods. Changes in nutrient status (e.g., normal to deficient, deficient to normal), were compared with immunological parameters in the same time periods using an autoregressive model. Results: Development of deficiency of vitamin A or vitamin B12 was associated with a decline in CD4 cell count (P = 0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B12 and zinc was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and 0.0112, respectively). These findings were largely unaffected by zidovudine use. For vitamin B12, low baseline status significantly predicted accelerated HIV-1 disease progression determined by CD4 cell count (P = 0.041) and the AIDS index (P = 0.005). Conclusions: These data suggest that micronutrient deficiencies are associated with HIV-1 disease progression and raise the possibility that normalization might increase symptom-free survival.
KW - Disease progression
KW - HIV-1 infection
KW - Nutrient status
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U2 - 10.1097/00002030-199509000-00010
DO - 10.1097/00002030-199509000-00010
M3 - Article
C2 - 8527077
AN - SCOPUS:0029161543
VL - 9
SP - 1051
EP - 1056
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 9
ER -