Microglial activation in different models of peripheral nerve injury of the rat

Stanislava Jergová, Dáša Čížková

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Pain and pain modulation has been viewed as being mediated entirely by neurons. However, new research implicates spinal cord glia as key players in the creation and maintenance of pathological pain. Sciatic nerve lesions are one of the most commonly studied pain-related injuries. In our study we aimed to characterize changes in microglial activation in the rat spinal cord after axotomy and chronic constriction injury of the sciatic nerve and to evaluate this activation in regard to pain behavior in injured and control groups of rats. Microglial activation was observed at ipsilateral side of lumbar spinal cord in all experimental groups. There were slight differences in the level and extent of microglial activation between nerve injury models used, however, differences were clear between nerve-injured and sham animals in accordance with different level of pain behavior in these groups. It is known that activated microglia release various chemical mediators that can excite pain-responsive neurons. Robust microglial activation observed in present study could therefore contribute to pathological pain states observed following nerve injury.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJournal of Molecular Histology
Volume38
Issue number3
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Allodynia
  • Microglia
  • Neuropathic pain
  • Peripheral nerve injury

ASJC Scopus subject areas

  • Histology
  • Physiology
  • Cell Biology

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