Microfluidic ion-sensing devices

R. Daniel Johnson, Vasilis G. Gavalas, Sylvia Daunert, Leonidas G. Bachas

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Quantitative determinations of ions in a variety of media have been performed traditionally via one of three approaches: optical instrumental methods (e.g., atomic absorption, and inductively-coupled plasma-optical emission or mass spectrometry), "wet" methods, or ion-selective sensors. Each of the approaches, though, possesses limitations including: power/reagent consumption and lack of portability for instrumental techniques; laborious sample-treatment steps for wet methods; and lack of selectivity and sensitivity with sensors when employed with complex samples. Microfluidic device have emerged as a solution to some of these challenges associated with ion analysis. Such systems can integrate multiple sample handling, calibration, and detection steps ("lab-on-a-chip" concept) into a footprint amenable to portability, while requiring small amounts of sample and power. Furthermore, devices can be constructed for multi-analyte detection, either through multiple parallel fluidic architectures or by using arrays of detection elements. This paper reviews recent progress in the development of total-analysis systems for ionic species. Fabrication techniques and various fluid-handling operations are discussed briefly, followed by a number of more mature strategies for microfluidic ion analysis. A variety of approaches expected to comprise the next generation of devices are also presented.

Original languageEnglish (US)
Pages (from-to)20-30
Number of pages11
JournalAnalytica Chimica Acta
Volume613
Issue number1
DOIs
StatePublished - Apr 14 2008

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Keywords

  • Ion analysis
  • Ion-selective sensors
  • Lab-on-a-chip
  • Micro-total analysis system
  • Microfluidics

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

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