Microfabrication of screen-printed nanoliter vials with embedded surface-modified electrodes

Jeffrey S. Lenihan, J. Christopher Ball, Vasilis G. Gavalas, Janet K. Lumpp, John Hines, Sylvia Daunert, Leonidas G Bachas

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A self-contained ion-selective sensing system within a nanoliter-volume vial has been developed by integrating screen printing, laser ablation, and molecular imprinting techniques. Screen printing and laser ablation are used in tandem to fabricate nanoliter-volume vials with carbon and Ag/AgCl ring electrodes embedded in the sidewalls. Using multisweep cyclic voltammetry, the surface of the carbon electrode can be modified with a polypyrrole film. By polymerizing pyrrole in the presence of nitrate, pores complementary to the nitrate anion in size, shape, and charge distribution are formed in the resulting film. Electrochemical cells modified with this nitrate-imprinted polypyrrole film show a near-Nernstian response to nitrate, and excellent reproducibility. The integration of molecular recognition and electrochemical response in the nanoliter vials is demonstrated by the detection of as little as 0.36 ng nitrate in nanoliter-volume samples. The integration of tailored molecular recognition within nanoliter vials via established fabrication and imprinting protocols should result in a number of nanosensor devices with applications in BioMEMS and micro total analysis systems.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalAnalytical and Bioanalytical Chemistry
Volume387
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Microtechnology
Microfabrication
Nitrates
Electrodes
Molecular recognition
Printing
Screen printing
Laser Therapy
Laser ablation
BioMEMS
Carbon
Molecular Imprinting
Micro-Electrical-Mechanical Systems
Nanosensors
Pyrroles
Electrochemical cells
Charge distribution
Cyclic voltammetry
Anions
Ions

Keywords

  • Ion-selective sensing
  • Microfabrication
  • Nanoliter vials

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Microfabrication of screen-printed nanoliter vials with embedded surface-modified electrodes. / Lenihan, Jeffrey S.; Ball, J. Christopher; Gavalas, Vasilis G.; Lumpp, Janet K.; Hines, John; Daunert, Sylvia; Bachas, Leonidas G.

In: Analytical and Bioanalytical Chemistry, Vol. 387, No. 1, 01.01.2007, p. 259-265.

Research output: Contribution to journalArticle

Lenihan, Jeffrey S. ; Ball, J. Christopher ; Gavalas, Vasilis G. ; Lumpp, Janet K. ; Hines, John ; Daunert, Sylvia ; Bachas, Leonidas G. / Microfabrication of screen-printed nanoliter vials with embedded surface-modified electrodes. In: Analytical and Bioanalytical Chemistry. 2007 ; Vol. 387, No. 1. pp. 259-265.
@article{1406eb0fe97b41c89666d51ff889dc0a,
title = "Microfabrication of screen-printed nanoliter vials with embedded surface-modified electrodes",
abstract = "A self-contained ion-selective sensing system within a nanoliter-volume vial has been developed by integrating screen printing, laser ablation, and molecular imprinting techniques. Screen printing and laser ablation are used in tandem to fabricate nanoliter-volume vials with carbon and Ag/AgCl ring electrodes embedded in the sidewalls. Using multisweep cyclic voltammetry, the surface of the carbon electrode can be modified with a polypyrrole film. By polymerizing pyrrole in the presence of nitrate, pores complementary to the nitrate anion in size, shape, and charge distribution are formed in the resulting film. Electrochemical cells modified with this nitrate-imprinted polypyrrole film show a near-Nernstian response to nitrate, and excellent reproducibility. The integration of molecular recognition and electrochemical response in the nanoliter vials is demonstrated by the detection of as little as 0.36 ng nitrate in nanoliter-volume samples. The integration of tailored molecular recognition within nanoliter vials via established fabrication and imprinting protocols should result in a number of nanosensor devices with applications in BioMEMS and micro total analysis systems.",
keywords = "Ion-selective sensing, Microfabrication, Nanoliter vials",
author = "Lenihan, {Jeffrey S.} and Ball, {J. Christopher} and Gavalas, {Vasilis G.} and Lumpp, {Janet K.} and John Hines and Sylvia Daunert and Bachas, {Leonidas G}",
year = "2007",
month = "1",
day = "1",
doi = "10.1007/s00216-006-0893-4",
language = "English",
volume = "387",
pages = "259--265",
journal = "Fresenius Zeitschrift fur Analytische Chemie",
issn = "0016-1152",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Microfabrication of screen-printed nanoliter vials with embedded surface-modified electrodes

AU - Lenihan, Jeffrey S.

AU - Ball, J. Christopher

AU - Gavalas, Vasilis G.

AU - Lumpp, Janet K.

AU - Hines, John

AU - Daunert, Sylvia

AU - Bachas, Leonidas G

PY - 2007/1/1

Y1 - 2007/1/1

N2 - A self-contained ion-selective sensing system within a nanoliter-volume vial has been developed by integrating screen printing, laser ablation, and molecular imprinting techniques. Screen printing and laser ablation are used in tandem to fabricate nanoliter-volume vials with carbon and Ag/AgCl ring electrodes embedded in the sidewalls. Using multisweep cyclic voltammetry, the surface of the carbon electrode can be modified with a polypyrrole film. By polymerizing pyrrole in the presence of nitrate, pores complementary to the nitrate anion in size, shape, and charge distribution are formed in the resulting film. Electrochemical cells modified with this nitrate-imprinted polypyrrole film show a near-Nernstian response to nitrate, and excellent reproducibility. The integration of molecular recognition and electrochemical response in the nanoliter vials is demonstrated by the detection of as little as 0.36 ng nitrate in nanoliter-volume samples. The integration of tailored molecular recognition within nanoliter vials via established fabrication and imprinting protocols should result in a number of nanosensor devices with applications in BioMEMS and micro total analysis systems.

AB - A self-contained ion-selective sensing system within a nanoliter-volume vial has been developed by integrating screen printing, laser ablation, and molecular imprinting techniques. Screen printing and laser ablation are used in tandem to fabricate nanoliter-volume vials with carbon and Ag/AgCl ring electrodes embedded in the sidewalls. Using multisweep cyclic voltammetry, the surface of the carbon electrode can be modified with a polypyrrole film. By polymerizing pyrrole in the presence of nitrate, pores complementary to the nitrate anion in size, shape, and charge distribution are formed in the resulting film. Electrochemical cells modified with this nitrate-imprinted polypyrrole film show a near-Nernstian response to nitrate, and excellent reproducibility. The integration of molecular recognition and electrochemical response in the nanoliter vials is demonstrated by the detection of as little as 0.36 ng nitrate in nanoliter-volume samples. The integration of tailored molecular recognition within nanoliter vials via established fabrication and imprinting protocols should result in a number of nanosensor devices with applications in BioMEMS and micro total analysis systems.

KW - Ion-selective sensing

KW - Microfabrication

KW - Nanoliter vials

UR - http://www.scopus.com/inward/record.url?scp=33845673776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845673776&partnerID=8YFLogxK

U2 - 10.1007/s00216-006-0893-4

DO - 10.1007/s00216-006-0893-4

M3 - Article

C2 - 17115139

AN - SCOPUS:33845673776

VL - 387

SP - 259

EP - 265

JO - Fresenius Zeitschrift fur Analytische Chemie

JF - Fresenius Zeitschrift fur Analytische Chemie

SN - 0016-1152

IS - 1

ER -