Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

Patricia Dauer, Alice Nomura, Ashok Saluja, Sulagna Banerjee

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Every year, nearly 300,000 people are diagnosed with pancreatic cancer worldwide, and an equivalent number succumb to this disease. One of the major challenges of pancreatic cancer that contributes to its poor survival rates is the development of resistance to the standard chemotherapy. Heterogeneity of the tumor, the dense fibroblastic stroma, and the aggressive biology of the tumor all contribute to the chemoresistant phenotype. In addition, the acellular components of the tumor microenvironment like hypoxia, stress pathways in the stromal cells, and the cytokines that are secreted by the immune cells, have a definitive role in orchestrating the chemoresistant property of the tumor. In this review, we systematically focus on the role played by the different microenvironmental components in determining chemoresistance of pancreatic tumors.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalPancreatology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Chemoresistance
  • Hypoxia
  • Metabolism
  • Tumor initiating cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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