Microdose gentamicin delivered via the round window microcatheter

A therapeutic option in Menière's disease

Peter Weisskopf, Michael E Hoffer, Richard D. Kopke, Kim Gottshall, Keith Allen, Derin Wester

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transtympanic gentamicin therapy is becoming an increasingly popular treatment for Menière's disease. Despite its popularity, transtympanic therapy is not without controversy. Vertigo cure rates are high, but hearing loss rates are variable. The best total dose of medicine, the best route of administration, and the best end-point of therapy have not been established. Meanwhile, the mode of action of gentamicin in controlling Menière's disease is still not completely understood. In the last several years, many groups have started to use a variety of sustained release devices to more accurately control the amount of gentamicin administered to the ear. This report discusses the use of one such sustained release device, and the effects of its use with very low doses of gentamicin, on the symptoms of Menière's disease.

Original languageEnglish (US)
Pages (from-to)154-156
Number of pages3
JournalOperative Techniques in Otolaryngology - Head and Neck Surgery
Volume12
Issue number3
StatePublished - 2001
Externally publishedYes

Fingerprint

Gentamicins
Equipment and Supplies
Vertigo
Therapeutics
Hearing Loss
Ear
Medicine

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Microdose gentamicin delivered via the round window microcatheter : A therapeutic option in Menière's disease. / Weisskopf, Peter; Hoffer, Michael E; Kopke, Richard D.; Gottshall, Kim; Allen, Keith; Wester, Derin.

In: Operative Techniques in Otolaryngology - Head and Neck Surgery, Vol. 12, No. 3, 2001, p. 154-156.

Research output: Contribution to journalArticle

Weisskopf, Peter ; Hoffer, Michael E ; Kopke, Richard D. ; Gottshall, Kim ; Allen, Keith ; Wester, Derin. / Microdose gentamicin delivered via the round window microcatheter : A therapeutic option in Menière's disease. In: Operative Techniques in Otolaryngology - Head and Neck Surgery. 2001 ; Vol. 12, No. 3. pp. 154-156.
@article{89b999139ce54b8481f295b46de98e25,
title = "Microdose gentamicin delivered via the round window microcatheter: A therapeutic option in Meni{\`e}re's disease",
abstract = "Transtympanic gentamicin therapy is becoming an increasingly popular treatment for Meni{\`e}re's disease. Despite its popularity, transtympanic therapy is not without controversy. Vertigo cure rates are high, but hearing loss rates are variable. The best total dose of medicine, the best route of administration, and the best end-point of therapy have not been established. Meanwhile, the mode of action of gentamicin in controlling Meni{\`e}re's disease is still not completely understood. In the last several years, many groups have started to use a variety of sustained release devices to more accurately control the amount of gentamicin administered to the ear. This report discusses the use of one such sustained release device, and the effects of its use with very low doses of gentamicin, on the symptoms of Meni{\`e}re's disease.",
author = "Peter Weisskopf and Hoffer, {Michael E} and Kopke, {Richard D.} and Kim Gottshall and Keith Allen and Derin Wester",
year = "2001",
language = "English (US)",
volume = "12",
pages = "154--156",
journal = "Operative Techniques in Otolaryngology - Head and Neck Surgery",
issn = "1043-1810",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Microdose gentamicin delivered via the round window microcatheter

T2 - A therapeutic option in Menière's disease

AU - Weisskopf, Peter

AU - Hoffer, Michael E

AU - Kopke, Richard D.

AU - Gottshall, Kim

AU - Allen, Keith

AU - Wester, Derin

PY - 2001

Y1 - 2001

N2 - Transtympanic gentamicin therapy is becoming an increasingly popular treatment for Menière's disease. Despite its popularity, transtympanic therapy is not without controversy. Vertigo cure rates are high, but hearing loss rates are variable. The best total dose of medicine, the best route of administration, and the best end-point of therapy have not been established. Meanwhile, the mode of action of gentamicin in controlling Menière's disease is still not completely understood. In the last several years, many groups have started to use a variety of sustained release devices to more accurately control the amount of gentamicin administered to the ear. This report discusses the use of one such sustained release device, and the effects of its use with very low doses of gentamicin, on the symptoms of Menière's disease.

AB - Transtympanic gentamicin therapy is becoming an increasingly popular treatment for Menière's disease. Despite its popularity, transtympanic therapy is not without controversy. Vertigo cure rates are high, but hearing loss rates are variable. The best total dose of medicine, the best route of administration, and the best end-point of therapy have not been established. Meanwhile, the mode of action of gentamicin in controlling Menière's disease is still not completely understood. In the last several years, many groups have started to use a variety of sustained release devices to more accurately control the amount of gentamicin administered to the ear. This report discusses the use of one such sustained release device, and the effects of its use with very low doses of gentamicin, on the symptoms of Menière's disease.

UR - http://www.scopus.com/inward/record.url?scp=0035168911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035168911&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 154

EP - 156

JO - Operative Techniques in Otolaryngology - Head and Neck Surgery

JF - Operative Techniques in Otolaryngology - Head and Neck Surgery

SN - 1043-1810

IS - 3

ER -