Microcantilever biosensors

R. Datar; A. Passian; R. Desikan; T. Thundat

doi:10.1109/ICSENS.2007.4388320

Microcantilever biosensors

R. Datar, A. Passian, R. Desikan, T. Thundat

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

Original language	English (US)
Title of host publication	The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Number of pages	1
DOIs	https://doi.org/10.1109/ICSENS.2007.4388320
State	Published - Dec 1 2007
Event	6th IEEE Conference on SENSORS, IEEE SENSORS 2007 - Atlanta, GA, United States Duration: Oct 28 2007 → Oct 31 2007

Publication series

Name	Proceedings of IEEE Sensors

Other

Other	6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Country	United States
City	Atlanta, GA
Period	10/28/07 → 10/31/07

Fingerprint

ASJC Scopus subject areas

Electrical and Electronic Engineering

Cite this

Datar, R., Passian, A., Desikan, R., & Thundat, T. (2007). Microcantilever biosensors. In The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007 [4388320] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2007.4388320

@inproceedings{f7ae9d83936a4a8bbca6df458bcfabe0,

title = "Microcantilever biosensors",

abstract = "Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.",

author = "R. Datar and A. Passian and R. Desikan and T. Thundat",

year = "2007",

month = dec

day = "1",

doi = "10.1109/ICSENS.2007.4388320",

language = "English (US)",

isbn = "1424412617",

series = "Proceedings of IEEE Sensors",

booktitle = "The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007",

note = "6th IEEE Conference on SENSORS, IEEE SENSORS 2007 ; Conference date: 28-10-2007 Through 31-10-2007",

}

TY - GEN

T1 - Microcantilever biosensors

AU - Datar, R.

AU - Passian, A.

AU - Desikan, R.

AU - Thundat, T.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

AB - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

UR - http://www.scopus.com/inward/record.url?scp=48349109342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48349109342&partnerID=8YFLogxK

U2 - 10.1109/ICSENS.2007.4388320

DO - 10.1109/ICSENS.2007.4388320

M3 - Conference contribution

AN - SCOPUS:48349109342

SN - 1424412617

SN - 9781424412617

T3 - Proceedings of IEEE Sensors

BT - The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007

T2 - 6th IEEE Conference on SENSORS, IEEE SENSORS 2007

Y2 - 28 October 2007 through 31 October 2007

ER -

Access to Document

10.1109/ICSENS.2007.4388320