TY - GEN
T1 - Microcantilever biosensors
AU - Datar, R.
AU - Passian, A.
AU - Desikan, R.
AU - Thundat, T.
N1 - Funding Information:
We acknowledge the help received from Drs. Sangmin Jeon, Arun Majumdar, Karen Stevenson, and Guanghua Wu. K.M.H. acknowledges support from Oak Ridge Associated Universities. Research sponsored by the Office of Biological and Environmental Research (OBER), U.S. DOE. Oak Ridge National Laboratory (ORNL) is managed by UT-Battelle, LLC for the U.S. Department of Energy under Contract No. DE-AC05-00OR22725.
PY - 2007
Y1 - 2007
N2 - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.
AB - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.
UR - http://www.scopus.com/inward/record.url?scp=48349109342&partnerID=8YFLogxK
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U2 - 10.1109/ICSENS.2007.4388320
DO - 10.1109/ICSENS.2007.4388320
M3 - Conference contribution
AN - SCOPUS:48349109342
SN - 1424412617
SN - 9781424412617
T3 - Proceedings of IEEE Sensors
SP - 5
BT - The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
T2 - 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Y2 - 28 October 2007 through 31 October 2007
ER -