Microcantilever biosensors

R. Datar; A. Passian; R. Desikan; T. Thundat

doi:10.1109/ICSENS.2007.4388320

Microcantilever biosensors

R. Datar, A. Passian, R. Desikan, T. Thundat

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

Original language	English (US)
Title of host publication	The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Number of pages	1
DOIs	https://doi.org/10.1109/ICSENS.2007.4388320
State	Published - Dec 1 2007
Event	6th IEEE Conference on SENSORS, IEEE SENSORS 2007 - Atlanta, GA, United States Duration: Oct 28 2007 → Oct 31 2007

Publication series

Name	Proceedings of IEEE Sensors

Other

Other	6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Country	United States
City	Atlanta, GA
Period	10/28/07 → 10/31/07

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/ICSENS.2007.4388320

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abstract = "Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.",

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AU - Passian, A.

AU - Desikan, R.

AU - Thundat, T.

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AB - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

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