Purpose . To determine the microbiological profile of patients using therapeutic soft contact lenses (TSCL) and prophylactic antibiotics after PRK. Methods .Ten consecutive patients undergoing excimer PRK had pre-operative conjunctival swabs for st mi-quantitative bacteriology. A TSCL (Protek BC 8.9,CIBAVision or lcuvue BC 8.4, J&J) was placed immediately after PRK. All patients w;re treated post-operatively with tobramycin 0.3% (Tomycine, CIBAVii.ion) 2x/d, diclofenac sodium 0.1% (Voltaren, CIBAVision) 2x/d, fluoromtholone 0.1% (FluorOp, CIBAVision) 4x/d and artificial tears (Hypotears, CIBAVision) 4x/d. At 5 days post-op, repeat conjunctival swabs were performed and TSCLs removed, for semi-quantitative bacteriology. Results . 5/10 (50%) preoperative conjunctival cultures were positive for bacterial growth including a variety of normal ocular flora. Of th: 5 positive pre-operative cultures, all conjunctival specimens were negati/e for growth post-operatively. 2/10 (20%) of TSCLs removed at day 5 were positive for bacterial growth, despite negative pre-op conjunctival cultures. Of the 2 positive TSCL cultures, 1 had a negative post-operati"e conjunctival culture. All patients had favorable clinical outcomes. Conclusion . Prophylactic tobramycin use may reduce positive conjunctival cultures post excimer PRK. TSCLs mayyield bacterial growth despite prophyh ctic tobramycin use. TSCLs may be safe and effective adjuncts after PRK when used carefully with prophylactic antibiotics.
|Original language||English (US)|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience