MHC polymorphism

AIDS susceptibility in non-human primates

Ronald E. Bontrop, David Watkins

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

One of the main host factors controlling resistance to disease appears to be the MHC. The recent poor results in HIV-1/AIDS Phase 3 vaccine field trials underline the importance of non-human primate models for AIDS. These models have been, and will continue to be, important for the definition of protective immune responses relevant to successful vaccine design because they supply essential information on the basic biology of lentivirus infections, mechanisms of resistance, escape and vaccine development.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalTrends in Immunology
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Primates
Acquired Immunodeficiency Syndrome
Vaccines
Lentivirus Infections
Disease Resistance
R Factors
HIV-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

MHC polymorphism : AIDS susceptibility in non-human primates. / Bontrop, Ronald E.; Watkins, David.

In: Trends in Immunology, Vol. 26, No. 4, 01.04.2005, p. 227-233.

Research output: Contribution to journalArticle

Bontrop, Ronald E. ; Watkins, David. / MHC polymorphism : AIDS susceptibility in non-human primates. In: Trends in Immunology. 2005 ; Vol. 26, No. 4. pp. 227-233.
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