MHC polymorphism: AIDS susceptibility in non-human primates

Ronald E. Bontrop, David I. Watkins

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

One of the main host factors controlling resistance to disease appears to be the MHC. The recent poor results in HIV-1/AIDS Phase 3 vaccine field trials underline the importance of non-human primate models for AIDS. These models have been, and will continue to be, important for the definition of protective immune responses relevant to successful vaccine design because they supply essential information on the basic biology of lentivirus infections, mechanisms of resistance, escape and vaccine development.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalTrends in Immunology
Volume26
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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