Methylprednisolone Pulse Therapy in Severe Dysthyroid Optic Neuropathy

John R. Guy, Steve Fagien, John P. Donovan, Melvin L. Rubin

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.

Original languageEnglish (US)
Pages (from-to)1048-1053
Number of pages6
Issue number7
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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