Methylation status in females with Rett syndrome

Michael Freilinger; David Kalisch; Adolf Müehl; Oskar Haas; Anne Moritz; Olaf Bodamer

doi:10.1177/0883073807302616

Methylation status in females with Rett syndrome

Michael Freilinger, David Kalisch, Adolf Müehl, Oskar Haas, Anne Moritz, Olaf Bodamer

Human Genetics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The authors studied methionine and creatine metabolism in females with Rett syndrome. Plasma metabolites (including methionine, homocysteine, guanidinoacetate) and urine creatine/creatinine ratios in 29 females with Rett syndrome were within the age-appropriate range. Although the authors have not been able to identify any abnormalities, it can be speculated that patients with Rett syndrome may benefit from dietary intervention to increase the supply of labile methyl groups to affected tissues.

Original language	English (US)
Pages (from-to)	635-638
Number of pages	4
Journal	Journal of child neurology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1177/0883073807302616
State	Published - May 2007

Keywords

Homocysteine
Methionine
Methylation
Rett syndrome

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health

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AU - Freilinger, Michael

AU - Kalisch, David

AU - Müehl, Adolf

AU - Haas, Oskar

AU - Moritz, Anne

AU - Bodamer, Olaf

PY - 2007/5

Y1 - 2007/5

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AB - The authors studied methionine and creatine metabolism in females with Rett syndrome. Plasma metabolites (including methionine, homocysteine, guanidinoacetate) and urine creatine/creatinine ratios in 29 females with Rett syndrome were within the age-appropriate range. Although the authors have not been able to identify any abnormalities, it can be speculated that patients with Rett syndrome may benefit from dietary intervention to increase the supply of labile methyl groups to affected tissues.

KW - Homocysteine

KW - Methionine

KW - Methylation

KW - Rett syndrome

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Methylation status in females with Rett syndrome

Abstract

Keywords

ASJC Scopus subject areas

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