Methylation status in females with Rett syndrome

Michael Freilinger, David Kalisch, Adolf Müehl, Oskar Haas, Anne Moritz, Olaf Bodamer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The authors studied methionine and creatine metabolism in females with Rett syndrome. Plasma metabolites (including methionine, homocysteine, guanidinoacetate) and urine creatine/creatinine ratios in 29 females with Rett syndrome were within the age-appropriate range. Although the authors have not been able to identify any abnormalities, it can be speculated that patients with Rett syndrome may benefit from dietary intervention to increase the supply of labile methyl groups to affected tissues.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalJournal of child neurology
Issue number5
StatePublished - May 2007


  • Homocysteine
  • Methionine
  • Methylation
  • Rett syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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