Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes

Begum Erdogan, Amma Bosompem, Dunfa Peng, Leng Han, Emily Smith, Mija E. Kennedy, Catherine E. Alford, Huiyun Wu, Zhongming Zhao, Claudio A. Mosse, Wael El-Rifai, Annette S. Kim

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.

Original languageEnglish (US)
Pages (from-to)2720-2727
Number of pages8
JournalLeukemia and Lymphoma
Volume54
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Host genes
  • Hypermethylation
  • MicroRNAs
  • Myelodysplastic syndrome
  • Myeloid maturation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Erdogan, B., Bosompem, A., Peng, D., Han, L., Smith, E., Kennedy, M. E., Alford, C. E., Wu, H., Zhao, Z., Mosse, C. A., El-Rifai, W., & Kim, A. S. (2013). Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. Leukemia and Lymphoma, 54(12), 2720-2727. https://doi.org/10.3109/10428194.2013.790542