Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes

Begum Erdogan, Amma Bosompem, Dunfa Peng, Leng Han, Emily Smith, Mija E. Kennedy, Catherine E. Alford, Huiyun Wu, Zhongming Zhao, Claudio A. Mosse, Wael El-Rifai, Annette S. Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.

Original languageEnglish (US)
Pages (from-to)2720-2727
Number of pages8
JournalLeukemia and Lymphoma
Volume54
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Myelodysplastic Syndromes
MicroRNAs
Methylation
Genes
Down-Regulation
Hematopoiesis
Hematologic Neoplasms
Epigenomics

Keywords

  • Host genes
  • Hypermethylation
  • MicroRNAs
  • Myelodysplastic syndrome
  • Myeloid maturation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Erdogan, B., Bosompem, A., Peng, D., Han, L., Smith, E., Kennedy, M. E., ... Kim, A. S. (2013). Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. Leukemia and Lymphoma, 54(12), 2720-2727. https://doi.org/10.3109/10428194.2013.790542

Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. / Erdogan, Begum; Bosompem, Amma; Peng, Dunfa; Han, Leng; Smith, Emily; Kennedy, Mija E.; Alford, Catherine E.; Wu, Huiyun; Zhao, Zhongming; Mosse, Claudio A.; El-Rifai, Wael; Kim, Annette S.

In: Leukemia and Lymphoma, Vol. 54, No. 12, 01.12.2013, p. 2720-2727.

Research output: Contribution to journalArticle

Erdogan, B, Bosompem, A, Peng, D, Han, L, Smith, E, Kennedy, ME, Alford, CE, Wu, H, Zhao, Z, Mosse, CA, El-Rifai, W & Kim, AS 2013, 'Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes', Leukemia and Lymphoma, vol. 54, no. 12, pp. 2720-2727. https://doi.org/10.3109/10428194.2013.790542
Erdogan, Begum ; Bosompem, Amma ; Peng, Dunfa ; Han, Leng ; Smith, Emily ; Kennedy, Mija E. ; Alford, Catherine E. ; Wu, Huiyun ; Zhao, Zhongming ; Mosse, Claudio A. ; El-Rifai, Wael ; Kim, Annette S. / Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. In: Leukemia and Lymphoma. 2013 ; Vol. 54, No. 12. pp. 2720-2727.
@article{e9551bf38e7d4b0ca513532c70e33196,
title = "Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes",
abstract = "Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.",
keywords = "Host genes, Hypermethylation, MicroRNAs, Myelodysplastic syndrome, Myeloid maturation",
author = "Begum Erdogan and Amma Bosompem and Dunfa Peng and Leng Han and Emily Smith and Kennedy, {Mija E.} and Alford, {Catherine E.} and Huiyun Wu and Zhongming Zhao and Mosse, {Claudio A.} and Wael El-Rifai and Kim, {Annette S.}",
year = "2013",
month = "12",
day = "1",
doi = "10.3109/10428194.2013.790542",
language = "English (US)",
volume = "54",
pages = "2720--2727",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes

AU - Erdogan, Begum

AU - Bosompem, Amma

AU - Peng, Dunfa

AU - Han, Leng

AU - Smith, Emily

AU - Kennedy, Mija E.

AU - Alford, Catherine E.

AU - Wu, Huiyun

AU - Zhao, Zhongming

AU - Mosse, Claudio A.

AU - El-Rifai, Wael

AU - Kim, Annette S.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.

AB - Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.

KW - Host genes

KW - Hypermethylation

KW - MicroRNAs

KW - Myelodysplastic syndrome

KW - Myeloid maturation

UR - http://www.scopus.com/inward/record.url?scp=84885010257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885010257&partnerID=8YFLogxK

U2 - 10.3109/10428194.2013.790542

DO - 10.3109/10428194.2013.790542

M3 - Article

C2 - 23547841

AN - SCOPUS:84885010257

VL - 54

SP - 2720

EP - 2727

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 12

ER -