Methotrexate therapy for ectopic pregnancy in adolescents

M. L. McCord, D. Muram, G. H. Lipscomb, M. P. Powell, K. L. Arheart

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Study Objective: To determine the suitability and efficacy of methotrexate (MTX) therapy for adolescent patients with ectopic pregnancy. Materials: Patients with ectopic pregnancy were treated with methotrexate, 50 mg/m2 intramuscularly. Follow-up determinations of quantitative βhCG levels were done on days 1, 4, and 7. They were then seen weekly until βhCG levels were less than 15 mIU/ml. Participants: Adolescents with ectopic pregnancy (55 patients) received MTX therapy and comprised the study group. They were compared with 186 adults similarly treated. The groups were compared for treatment outcome and for compliance with the rigid protocol requirements. Main outcome measures: Treatment success was defined as a patient who required no surgical intervention and whose βhCG levels declined to < 15 mIU/ml. Results: 85% of patients required no surgical intervention following MTX injection. Surgical intervention rates were slightly higher and success rates slightly lower for adolescent patients, but these differences were not statistically significant (p = .71). Although adult patients were more likely to have a perfect compliance rating, comparison of all compliance categories showed no significant differences p = .17). Conclusions: MTX therapy is satisfactory for adolescent patients. It is effective, and adolescent patients are able to comply with the requirements of a rigid protocol.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalJournal of Pediatric and Adolescent Gynecology
Issue number2
StatePublished - Apr 1996


  • Ectopic pregnancy
  • Methotrexate compliance
  • Pregnancy in adolescents

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health


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