Methionine-Enkephalin Stimulates Gastric Secretion and Gastric Mucosal Blood Flow

Stanislaw J. Konturek; Wieslaw Pawlik; Kazimierz M. Waluś; David H. Coy; Andrew V. Schally

doi:10.3181/00379727-158-40161

Methionine-Enkephalin Stimulates Gastric Secretion and Gastric Mucosal Blood Flow

Stanislaw J. Konturek, Wieslaw Pawlik, Kazimierz M. Waluś, David H. Coy, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Intra-arterial infusion of methionine-enkaphalin or morphine caused a dose-dependent increase in histamine-induced gastric secretion and gastric mucosal blood flow. Administration of naloxone resulted in the reduction of both gastric secretion and mucosal circulation indicating that oxyntic cells possess specific opiate receptors and that opiate peptides may be involved in the stimulation of gastric secretion.

Original language	English (US)
Pages (from-to)	156-160
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	158
Issue number	2
DOIs	https://doi.org/10.3181/00379727-158-40161
State	Published - Jun 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Intra-arterial infusion of methionine-enkaphalin or morphine caused a dose-dependent increase in histamine-induced gastric secretion and gastric mucosal blood flow. Administration of naloxone resulted in the reduction of both gastric secretion and mucosal circulation indicating that oxyntic cells possess specific opiate receptors and that opiate peptides may be involved in the stimulation of gastric secretion.",

author = "Konturek, {Stanislaw J.} and Wieslaw Pawlik and Walu{\'s}, {Kazimierz M.} and Coy, {David H.} and Schally, {Andrew V.}",

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AU - Coy, David H.

AU - Schally, Andrew V.

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AB - Intra-arterial infusion of methionine-enkaphalin or morphine caused a dose-dependent increase in histamine-induced gastric secretion and gastric mucosal blood flow. Administration of naloxone resulted in the reduction of both gastric secretion and mucosal circulation indicating that oxyntic cells possess specific opiate receptors and that opiate peptides may be involved in the stimulation of gastric secretion.

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