Methionine-enkephalin stimulates gastric secretion and gastric mucosal blood flow

S. J. Konturek, W. Pawlik, K. M. Walus, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Intra-arterial infusion of methionine-enkaphalin or morphine caused a dose-dependent increase in histamine-induced gastric secretion and gastric mucosal blood flow. Administration of naloxone resulted in the reduction of both gastric secretion and mucosal circulation indicating that oxyntic cells possess specific opiate receptors and that opiate peptides may be involved in the stimulation of gastric secretion.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume158
Issue number2
StatePublished - Dec 1 1978
Externally publishedYes

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Methionine Enkephalin
Opioid Peptides
Opioid Receptors
Naloxone
Methionine
Morphine
Histamine
Stomach
Blood
Gastric Parietal Cells
Intra Arterial Infusions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Methionine-enkephalin stimulates gastric secretion and gastric mucosal blood flow. / Konturek, S. J.; Pawlik, W.; Walus, K. M.; Coy, D. H.; Schally, Andrew V.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 158, No. 2, 01.12.1978, p. 156-160.

Research output: Contribution to journalArticle

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