Methionine-Enkephalin Stimulates Gastric Secretion and Gastric Mucosal Blood Flow

Stanislaw J. Konturek, Wieslaw Pawlik, Kazimierz M. Waluś, David H. Coy, Andrew V. Schally

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Intra-arterial infusion of methionine-enkaphalin or morphine caused a dose-dependent increase in histamine-induced gastric secretion and gastric mucosal blood flow. Administration of naloxone resulted in the reduction of both gastric secretion and mucosal circulation indicating that oxyntic cells possess specific opiate receptors and that opiate peptides may be involved in the stimulation of gastric secretion.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume158
Issue number2
DOIs
StatePublished - Jun 1978

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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