Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice

Syed Z. Imam; Yossef Itzhak; Jean L. Cadet; Fakhrul Islam; William Slikker; Syed F. Ali

doi:10.1016/S0169-328X(01)00139-5

Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice

Syed Z. Imam, Yossef Itzhak, Jean L. Cadet, Fakhrul Islam, William Slikker, Syed F. Ali

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.

Original language	English (US)
Pages (from-to)	174-178
Number of pages	5
Journal	Molecular Brain Research
Volume	91
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(01)00139-5
State	Published - Jul 13 2001

Keywords

Gene expression
Methamphetamine
Peroxynitrite
Transgenic mouse

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice",

abstract = "Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.",

keywords = "Gene expression, Methamphetamine, Peroxynitrite, Transgenic mouse",

author = "Imam, {Syed Z.} and Yossef Itzhak and Cadet, {Jean L.} and Fakhrul Islam and William Slikker and Ali, {Syed F.}",

note = "Funding Information: This research was supported in part by an appointment (S.Z.I.) to the Research Participation Program at the National Center for Toxicological Research administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0169-328X(01)00139-5",

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T1 - Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice

AU - Imam, Syed Z.

AU - Itzhak, Yossef

AU - Cadet, Jean L.

AU - Islam, Fakhrul

AU - Slikker, William

AU - Ali, Syed F.

N1 - Funding Information: This research was supported in part by an appointment (S.Z.I.) to the Research Participation Program at the National Center for Toxicological Research administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2001/7/13

Y1 - 2001/7/13

N2 - Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.

AB - Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.

KW - Gene expression

KW - Methamphetamine

KW - Peroxynitrite

KW - Transgenic mouse

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