Abstract
Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.
| Original language | English |
|---|---|
| Pages (from-to) | 174-178 |
| Number of pages | 5 |
| Journal | Molecular Brain Research |
| Volume | 91 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 13 2001 |
Fingerprint
Keywords
- Gene expression
- Methamphetamine
- Peroxynitrite
- Transgenic mouse
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice. / Imam, Syed Z.; Itzhak, Yossef; Cadet, Jean L.; Islam, Fakhrul; Slikker, William; Ali, Syed F.
In: Molecular Brain Research, Vol. 91, No. 1-2, 13.07.2001, p. 174-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice
AU - Imam, Syed Z.
AU - Itzhak, Yossef
AU - Cadet, Jean L.
AU - Islam, Fakhrul
AU - Slikker, William
AU - Ali, Syed F.
PY - 2001/7/13
Y1 - 2001/7/13
N2 - Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.
AB - Methamphetamine (METH)-induced alterations in the expression of p53 and bcl-2 protein were studied in the striatum of wild type, neuronal nitric oxide synthase knockout (nNOS -/-) and copper zinc superoxide dismutase overexpressed (SOD-Tg) mice. METH treatment up-regulated p53 and down-regulated bcl-2 expression in the striatum of wild type mice. No significant alterations were observed in the expression of these proteins in the nNOS -/- or SOD-Tg mice. These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery.
KW - Gene expression
KW - Methamphetamine
KW - Peroxynitrite
KW - Transgenic mouse
UR - http://www.scopus.com/inward/record.url?scp=0035854491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035854491&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(01)00139-5
DO - 10.1016/S0169-328X(01)00139-5
M3 - Article
C2 - 11457507
AN - SCOPUS:0035854491
VL - 91
SP - 174
EP - 178
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -