Methamphetamine-associated dysregulation of the hypothalamic–pituitary–thyroid axis

Deborah L. Jones, Adam W. Carrico, Suat Babayigit, Violeta J. Rodriguez, Carlos Aguila, Mahendra Kumar

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Methamphetamine and HIV impair thyroid function, but few studies have investigated their combined effects on thyroid dysregulation. This study examined the associations of methamphetamine use alone and in combination with HIV on thyroid function among men in South Florida. Measures of thyroid function in methamphetamine- using, HIV-infected (METH+HIV+; n = 127) and HIV-negative (METH+HIV-; n = 46) men who have sex with men (MSM) were compared to non-methamphetamine- using, HIV-negative men (METH-HIV-; n = 136). Thyroid function was dysregulated in methamphetamine- using MSM, irrespective of HIV status. Both meth-using groups had greater odds of abnormal thyroid stimulating hormone levels and significantly higher mean free triiodothyronine (T3) levels. Elevated free T3 was associated with greater depressive symptoms. Overall, outcomes have important implications for assessment of thyroid function in methamphetamine users, particularly among those presenting with depression.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalJournal of Behavioral Medicine
Volume41
Issue number6
DOIs
StatePublished - 2018

Keywords

  • Depression
  • HIV
  • Methamphetamine
  • Thyroid hormones
  • Trauma

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

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