Metastatic Uterine Carcinosarcoma to the Orbit

Sana Qureshi, Nimesh A. Patel, Nish Patel, Mark P. Ghassibi, David T. Tse, Sander R. Dubovy

Research output: Contribution to journalArticlepeer-review


Metastases of solid tumors to the eye and ocular adnexa are rare. Herein, the authors describe the clinical, histologic, and immunohistochemical findings of a patient with a history of adenocarcinoma of the colon and a uterine carcinosarcoma (malignant mixed Müllerian tumor) who presented with proptosis and decreased vision. Positive staining with PAX-8, p16 and negative reaction for CK20 and CDX2 helped to establish the uterine origin of the metastasis. This rare case demonstrates the utility of immunohistochemical probes, especially in patients with a complex oncological history, where multiple primary sources of the metastasis are in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)e198-e202
JournalOphthalmic plastic and reconstructive surgery
Issue number6
StatePublished - Nov 1 2021

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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