Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma

J. William Harbour, D. H. Char, S. Kroll, J. M. Quivey, J. Castro, E. S. Gragoudas, K. M. Egan

Research output: Contribution to journalArticle

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Abstract

Objective: The purpose of the study is to compare the prognostic significance of horizontal/marginal versus vertical/diffuse patterns of postirradiation local recurrence of posterior uveal melanoma. Design: The study design was a nonrandomized, retrospective clinical study. Semiparametric and nonparametric statistical techniques were used. Participants: Seven hundred sixty-six posterior uveal melanoma patients were studied. Intervention: Either iodine-125 plaque or helium ion radiation therapy was performed. Main Outcome Measures: Local tumor recurrence and systemic metastasis were measured. Results: Local tumor recurrence was detected in 66 (8.6%) of 766 irradiated tumors. The 5-year actuarial rate of local recurrence was 10%. The recurrence pattern was horizontal/marginal in 27 patients (41%) and vertical/diffuse in 39 patients (59%). Systemic metastasis was detected in 5 patients (19%) with horizontal/marginal recurrence and in 19 patients (49%) with vertical/diffuse recurrence. After known metastatic risk factors were controlled, the relative risk for metastasis was 2.2 for horizontal/marginal recurrence and 5.1 for vertical/diffuse recurrence (P = 0.05). The actuarial rate of systemic metastasis was 2.9% per year for all patients, 6.3% per year for patients with horizontal/marginal recurrence, and 15.5% per year for patients with vertical/diffuse recurrence. Conclusions: Postirradiation local recurrence of posterior uveal melanoma is a risk factor for systemic metastasis. Vertical/diffuse recurrences may be associated more strongly with metastatic disease than horizontal/marginal recurrences.

Original languageEnglish
Pages (from-to)1785-1793
Number of pages9
JournalOphthalmology
Volume104
Issue number11
StatePublished - Dec 1 1997
Externally publishedYes

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Recurrence
Neoplasm Metastasis
Uveal melanoma
Neoplasms
Helium
Iodine
Radiotherapy
Retrospective Studies
Outcome Assessment (Health Care)
Ions

ASJC Scopus subject areas

  • Ophthalmology

Cite this

William Harbour, J., Char, D. H., Kroll, S., Quivey, J. M., Castro, J., Gragoudas, E. S., & Egan, K. M. (1997). Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma. Ophthalmology, 104(11), 1785-1793.

Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma. / William Harbour, J.; Char, D. H.; Kroll, S.; Quivey, J. M.; Castro, J.; Gragoudas, E. S.; Egan, K. M.

In: Ophthalmology, Vol. 104, No. 11, 01.12.1997, p. 1785-1793.

Research output: Contribution to journalArticle

William Harbour, J, Char, DH, Kroll, S, Quivey, JM, Castro, J, Gragoudas, ES & Egan, KM 1997, 'Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma', Ophthalmology, vol. 104, no. 11, pp. 1785-1793.
William Harbour J, Char DH, Kroll S, Quivey JM, Castro J, Gragoudas ES et al. Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma. Ophthalmology. 1997 Dec 1;104(11):1785-1793.
William Harbour, J. ; Char, D. H. ; Kroll, S. ; Quivey, J. M. ; Castro, J. ; Gragoudas, E. S. ; Egan, K. M. / Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma. In: Ophthalmology. 1997 ; Vol. 104, No. 11. pp. 1785-1793.
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abstract = "Objective: The purpose of the study is to compare the prognostic significance of horizontal/marginal versus vertical/diffuse patterns of postirradiation local recurrence of posterior uveal melanoma. Design: The study design was a nonrandomized, retrospective clinical study. Semiparametric and nonparametric statistical techniques were used. Participants: Seven hundred sixty-six posterior uveal melanoma patients were studied. Intervention: Either iodine-125 plaque or helium ion radiation therapy was performed. Main Outcome Measures: Local tumor recurrence and systemic metastasis were measured. Results: Local tumor recurrence was detected in 66 (8.6{\%}) of 766 irradiated tumors. The 5-year actuarial rate of local recurrence was 10{\%}. The recurrence pattern was horizontal/marginal in 27 patients (41{\%}) and vertical/diffuse in 39 patients (59{\%}). Systemic metastasis was detected in 5 patients (19{\%}) with horizontal/marginal recurrence and in 19 patients (49{\%}) with vertical/diffuse recurrence. After known metastatic risk factors were controlled, the relative risk for metastasis was 2.2 for horizontal/marginal recurrence and 5.1 for vertical/diffuse recurrence (P = 0.05). The actuarial rate of systemic metastasis was 2.9{\%} per year for all patients, 6.3{\%} per year for patients with horizontal/marginal recurrence, and 15.5{\%} per year for patients with vertical/diffuse recurrence. Conclusions: Postirradiation local recurrence of posterior uveal melanoma is a risk factor for systemic metastasis. Vertical/diffuse recurrences may be associated more strongly with metastatic disease than horizontal/marginal recurrences.",
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AU - William Harbour, J.

AU - Char, D. H.

AU - Kroll, S.

AU - Quivey, J. M.

AU - Castro, J.

AU - Gragoudas, E. S.

AU - Egan, K. M.

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N2 - Objective: The purpose of the study is to compare the prognostic significance of horizontal/marginal versus vertical/diffuse patterns of postirradiation local recurrence of posterior uveal melanoma. Design: The study design was a nonrandomized, retrospective clinical study. Semiparametric and nonparametric statistical techniques were used. Participants: Seven hundred sixty-six posterior uveal melanoma patients were studied. Intervention: Either iodine-125 plaque or helium ion radiation therapy was performed. Main Outcome Measures: Local tumor recurrence and systemic metastasis were measured. Results: Local tumor recurrence was detected in 66 (8.6%) of 766 irradiated tumors. The 5-year actuarial rate of local recurrence was 10%. The recurrence pattern was horizontal/marginal in 27 patients (41%) and vertical/diffuse in 39 patients (59%). Systemic metastasis was detected in 5 patients (19%) with horizontal/marginal recurrence and in 19 patients (49%) with vertical/diffuse recurrence. After known metastatic risk factors were controlled, the relative risk for metastasis was 2.2 for horizontal/marginal recurrence and 5.1 for vertical/diffuse recurrence (P = 0.05). The actuarial rate of systemic metastasis was 2.9% per year for all patients, 6.3% per year for patients with horizontal/marginal recurrence, and 15.5% per year for patients with vertical/diffuse recurrence. Conclusions: Postirradiation local recurrence of posterior uveal melanoma is a risk factor for systemic metastasis. Vertical/diffuse recurrences may be associated more strongly with metastatic disease than horizontal/marginal recurrences.

AB - Objective: The purpose of the study is to compare the prognostic significance of horizontal/marginal versus vertical/diffuse patterns of postirradiation local recurrence of posterior uveal melanoma. Design: The study design was a nonrandomized, retrospective clinical study. Semiparametric and nonparametric statistical techniques were used. Participants: Seven hundred sixty-six posterior uveal melanoma patients were studied. Intervention: Either iodine-125 plaque or helium ion radiation therapy was performed. Main Outcome Measures: Local tumor recurrence and systemic metastasis were measured. Results: Local tumor recurrence was detected in 66 (8.6%) of 766 irradiated tumors. The 5-year actuarial rate of local recurrence was 10%. The recurrence pattern was horizontal/marginal in 27 patients (41%) and vertical/diffuse in 39 patients (59%). Systemic metastasis was detected in 5 patients (19%) with horizontal/marginal recurrence and in 19 patients (49%) with vertical/diffuse recurrence. After known metastatic risk factors were controlled, the relative risk for metastasis was 2.2 for horizontal/marginal recurrence and 5.1 for vertical/diffuse recurrence (P = 0.05). The actuarial rate of systemic metastasis was 2.9% per year for all patients, 6.3% per year for patients with horizontal/marginal recurrence, and 15.5% per year for patients with vertical/diffuse recurrence. Conclusions: Postirradiation local recurrence of posterior uveal melanoma is a risk factor for systemic metastasis. Vertical/diffuse recurrences may be associated more strongly with metastatic disease than horizontal/marginal recurrences.

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