Metastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapy

Rup Tandan, Reid Taylor, Damian P. DiCostanzo, Khema Sharma, Timothy Fries, John Roberts

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Myasthenia gravis (MG) occurs in up to 44% of patients with thymoma. Thirty-three percent of these neoplasms are invasive but extrathoracic disease is rare. Recently, we saw a patient with MG and recurrent, metastasizing mixed lymphoepithelial thymoma, whose disease was resistant to combination chemotherapy and radiotherapy but who responded dramatically to treatment with daily glucocorticoids. Thus, therapy with daily glucocorticoids should be considered in the treatment of invasive or metastatic thymoma associated with MG, including when conventional surgery, radiotherapy, and chemotherapy have failed.

Original languageEnglish (US)
Pages (from-to)1286-1290
Number of pages5
JournalCancer
Volume65
Issue number6
DOIs
StatePublished - Mar 15 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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