Metastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapy

R. Tandan, R. Taylor, D. P. DiCostanzo, Khema R Sharma, T. Fries, J. Roberts

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Myasthenia gravis (MG) occurs in up to 44% of patients with thymoma. Thirty-three percent of these neoplasms are invasive but extrathoracic disease is rare. Recently, we saw a patient with MG and recurrent, metastasizing mixed lymphoepithelial thymoma, whose disease was resistant to combination chemotherapy and radiotherapy but who responded dramatically to treatment with daily glucocorticoids. Thus, therapy with daily glucocorticoids should be considered in the treatment of invasive or metastatic thymoma associated with MG, including when conventional surgery, radiotherapy, and chemotherapy have failed.

Original languageEnglish
Pages (from-to)1286-1290
Number of pages5
JournalCancer
Volume65
Issue number6
StatePublished - Jan 1 1990
Externally publishedYes

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Thymoma
Myasthenia Gravis
Glucocorticoids
Radiotherapy
Drug Therapy
Rare Diseases
Combination Drug Therapy
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Metastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapy. / Tandan, R.; Taylor, R.; DiCostanzo, D. P.; Sharma, Khema R; Fries, T.; Roberts, J.

In: Cancer, Vol. 65, No. 6, 01.01.1990, p. 1286-1290.

Research output: Contribution to journalArticle

Tandan, R, Taylor, R, DiCostanzo, DP, Sharma, KR, Fries, T & Roberts, J 1990, 'Metastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapy', Cancer, vol. 65, no. 6, pp. 1286-1290.
Tandan, R. ; Taylor, R. ; DiCostanzo, D. P. ; Sharma, Khema R ; Fries, T. ; Roberts, J. / Metastasizing thymoma and myasthenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiation therapy. In: Cancer. 1990 ; Vol. 65, No. 6. pp. 1286-1290.
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