Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs

M. E. Hines, J. C. Newton, N. H. Altman, T. N. Hribernik, H. W. Casey

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8 Scopus citations


Extra-adrenal paragangliomas associated with vertebral pain and clinical neurological abnormalities as a result of metastasis to the vertebral column were diagnosed in four dogs of different breeds by light microscopy. All were males (two intact and two neutered) aged 8 years. Metastatic neoplasms occurred as extradural masses with associated bone lysis at vertebrae C4 (2 cases), T12-L1 (1 case) and L4 (1 case). The neoplastic cells exhibited similar morphology with little variation between cases. All neoplasms showed cytoplasmic granules after staining with the Churukian-Schenk modification of the Pascual argyrophil stain for neurosecretory granules or for membrane bound electron-dense granules (dense-core granules). On immunohistochemical examination the neoplastic cells gave positive results for neuron-specific enolase and negative results for chromogranin and epithelial membrane antigen. Multiple organ metastasis and metastasis to bone have been reported previously, but these cases were unusual due to the involvement of the spine as an apparent predilection site for metastasis, and the sex (male) and age of the animals affected.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalJournal of Comparative Pathology
Issue number3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)


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