Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs

M. E. Hines, J. C. Newton, N. H. Altman, T. N. Hribernik, H. W. Casey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Extra-adrenal paragangliomas associated with vertebral pain and clinical neurological abnormalities as a result of metastasis to the vertebral column were diagnosed in four dogs of different breeds by light microscopy. All were males (two intact and two neutered) aged 8 years. Metastatic neoplasms occurred as extradural masses with associated bone lysis at vertebrae C4 (2 cases), T12-L1 (1 case) and L4 (1 case). The neoplastic cells exhibited similar morphology with little variation between cases. All neoplasms showed cytoplasmic granules after staining with the Churukian-Schenk modification of the Pascual argyrophil stain for neurosecretory granules or for membrane bound electron-dense granules (dense-core granules). On immunohistochemical examination the neoplastic cells gave positive results for neuron-specific enolase and negative results for chromogranin and epithelial membrane antigen. Multiple organ metastasis and metastasis to bone have been reported previously, but these cases were unusual due to the involvement of the spine as an apparent predilection site for metastasis, and the sex (male) and age of the animals affected.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalJournal of Comparative Pathology
Volume108
Issue number3
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Extra-Adrenal Paraganglioma
metastasis
Dogs
Neoplasm Metastasis
granules
Spine
dogs
spine (bones)
bones
Chromogranins
cytoplasmic granules
Cytoplasmic Granules
Bone and Bones
Mucin-1
phosphopyruvate hydratase
neoplasms
Phosphopyruvate Hydratase
dog breeds
vertebrae
dyes

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Hines, M. E., Newton, J. C., Altman, N. H., Hribernik, T. N., & Casey, H. W. (1993). Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs. Journal of Comparative Pathology, 108(3), 283-290.

Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs. / Hines, M. E.; Newton, J. C.; Altman, N. H.; Hribernik, T. N.; Casey, H. W.

In: Journal of Comparative Pathology, Vol. 108, No. 3, 01.01.1993, p. 283-290.

Research output: Contribution to journalArticle

Hines, ME, Newton, JC, Altman, NH, Hribernik, TN & Casey, HW 1993, 'Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs', Journal of Comparative Pathology, vol. 108, no. 3, pp. 283-290.
Hines ME, Newton JC, Altman NH, Hribernik TN, Casey HW. Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs. Journal of Comparative Pathology. 1993 Jan 1;108(3):283-290.
Hines, M. E. ; Newton, J. C. ; Altman, N. H. ; Hribernik, T. N. ; Casey, H. W. / Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs. In: Journal of Comparative Pathology. 1993 ; Vol. 108, No. 3. pp. 283-290.
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