Metabolite 1H relaxation in normal and hyponatremic brain

William D. Rooney, Toshihiko Ebisu, Anthony Mancuso, Steven Graham, Michael W. Weiner, Andrew A Maudsley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Proton spin relaxation rate constants in normal and hyponatremic rat brain were measured to determine the sensitivity of metabolite relaxation properties to cytotoxic edema and to quantify metabolite concentration in normal and edematous brain. Relaxation rate constants for protons of water and spectral regions with dominant contributions from methyl protons of cholines (Cho), creatines (Cr), N-acetylaspartate (NA), and lactate (Lac), and for methylene protons of glutamate (Glu) were measured at 7 T. Changes in metabolite relaxation properties associated with cytotoxic edema were a decrease in the Cr longitudinal rate constant, from 0.63 ± 0.02 s-1 (mean ± SE) in controls to 0.50 ± 0.03 s-1 in edematous brain, and an increase in the transverse rate constant of NA from 5.3 ± 0.2 s-1 in controls to 6.6 ± 0.3 s-1 in edematous brain. Four hours after induction of hyponatremia, there was a 14% reduction in summed metabolite concentrations of Cho, Cr, and NA, and a 200% increase in Lac signal intensity. It is concluded that changes in both metabolite spin relaxation and detectable spin concentration accompany the cerebral pathology of cytotoxic edema complicated with secondary ischemia.

Original languageEnglish
Pages (from-to)688-696
Number of pages9
JournalMagnetic Resonance in Medicine
Volume35
Issue number5
DOIs
StatePublished - May 1 1996
Externally publishedYes

Fingerprint

Creatine
Protons
Brain
Choline
Lactic Acid
Edema
Hyponatremia
Brain Edema
Glutamic Acid
Ischemia
Pathology
Water
N-acetylaspartate

Keywords

  • cytotoxic edema
  • quantitative magnetic resonance spectroscopy
  • rat brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Metabolite 1H relaxation in normal and hyponatremic brain. / Rooney, William D.; Ebisu, Toshihiko; Mancuso, Anthony; Graham, Steven; Weiner, Michael W.; Maudsley, Andrew A.

In: Magnetic Resonance in Medicine, Vol. 35, No. 5, 01.05.1996, p. 688-696.

Research output: Contribution to journalArticle

Rooney, WD, Ebisu, T, Mancuso, A, Graham, S, Weiner, MW & Maudsley, AA 1996, 'Metabolite 1H relaxation in normal and hyponatremic brain', Magnetic Resonance in Medicine, vol. 35, no. 5, pp. 688-696. https://doi.org/10.1002/mrm.1910350510
Rooney, William D. ; Ebisu, Toshihiko ; Mancuso, Anthony ; Graham, Steven ; Weiner, Michael W. ; Maudsley, Andrew A. / Metabolite 1H relaxation in normal and hyponatremic brain. In: Magnetic Resonance in Medicine. 1996 ; Vol. 35, No. 5. pp. 688-696.
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