Metabolism, energetics, and lipid biology in the podocyte - Cellular cholesterol mediated glomerular injury

Sandra Merscher, Christopher E. Pedigo, Armando J. Mendez

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Chronic kidney disease (CKD) is associated with a high risk of death. Dyslipidemia is commonly observed in patients with CKD and is accompanied by a decrease in plasma high-density lipoprotein (HDL), and an increase in plasma triglyceride-rich lipoproteins and oxidized lipids. The observation that statins may decrease albuminuria but do not stop the progression of CKD indicates that pathways other than the cholesterol synthesis contribute to cholesterol accumulation in the kidneys of patients with CKD.

Original languageEnglish (US)
Article number169
JournalFrontiers in Endocrinology
Volume5
Issue numberSEP
DOIs
StatePublished - 2014

Keywords

  • ABCA1
  • Apolipoprotein
  • Cholesterol
  • Glomerular disease
  • Kidney disease
  • Nephropathy
  • Podocyte
  • Renal disease
  • Reverse cholesterol transport

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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