Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys

Jeremy D. Coplan, Chadi G. Abdallah, Sanjay J. Mathew, Dikoma C. Shungu, Xiangling Mao, Eric L P Smith, Daniel Kaufman, Jack M. Gorman, Michael J. Owens, Charles Nemeroff, Mary Ann Banerji, Leonard A. Rosenblum, John G. Kral

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls. Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI; sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators. Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator. Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalPhysiology and Behavior
Volume103
Issue number5
DOIs
StatePublished - Jul 6 2011

Fingerprint

Macaca radiata
Corticotropin-Releasing Hormone
Cerebrospinal Fluid
Hippocampus
Psychological Stress
Abdominal Obesity
Sagittal Abdominal Diameter
Obesity
Insulin
Food Supply
Creatine
Choline
Neuropeptides
Statistical Factor Analysis
Haplorhini
Insulin Resistance
Fasting
Body Mass Index
Mothers
Magnetic Resonance Imaging

Keywords

  • Corticotropin releasing factor
  • Food insecurity
  • Hippocampus
  • Metabolic syndrome
  • Obesity
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Coplan, J. D., Abdallah, C. G., Mathew, S. J., Shungu, D. C., Mao, X., Smith, E. L. P., ... Kral, J. G. (2011). Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. Physiology and Behavior, 103(5), 535-539. https://doi.org/10.1016/j.physbeh.2011.03.020

Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. / Coplan, Jeremy D.; Abdallah, Chadi G.; Mathew, Sanjay J.; Shungu, Dikoma C.; Mao, Xiangling; Smith, Eric L P; Kaufman, Daniel; Gorman, Jack M.; Owens, Michael J.; Nemeroff, Charles; Banerji, Mary Ann; Rosenblum, Leonard A.; Kral, John G.

In: Physiology and Behavior, Vol. 103, No. 5, 06.07.2011, p. 535-539.

Research output: Contribution to journalArticle

Coplan, JD, Abdallah, CG, Mathew, SJ, Shungu, DC, Mao, X, Smith, ELP, Kaufman, D, Gorman, JM, Owens, MJ, Nemeroff, C, Banerji, MA, Rosenblum, LA & Kral, JG 2011, 'Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys', Physiology and Behavior, vol. 103, no. 5, pp. 535-539. https://doi.org/10.1016/j.physbeh.2011.03.020
Coplan, Jeremy D. ; Abdallah, Chadi G. ; Mathew, Sanjay J. ; Shungu, Dikoma C. ; Mao, Xiangling ; Smith, Eric L P ; Kaufman, Daniel ; Gorman, Jack M. ; Owens, Michael J. ; Nemeroff, Charles ; Banerji, Mary Ann ; Rosenblum, Leonard A. ; Kral, John G. / Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. In: Physiology and Behavior. 2011 ; Vol. 103, No. 5. pp. 535-539.
@article{f70f1cfd8fa74d2998c3081dacb12d24,
title = "Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys",
abstract = "Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls. Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI; sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators. Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator. Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity.",
keywords = "Corticotropin releasing factor, Food insecurity, Hippocampus, Metabolic syndrome, Obesity, Stress",
author = "Coplan, {Jeremy D.} and Abdallah, {Chadi G.} and Mathew, {Sanjay J.} and Shungu, {Dikoma C.} and Xiangling Mao and Smith, {Eric L P} and Daniel Kaufman and Gorman, {Jack M.} and Owens, {Michael J.} and Charles Nemeroff and Banerji, {Mary Ann} and Rosenblum, {Leonard A.} and Kral, {John G.}",
year = "2011",
month = "7",
day = "6",
doi = "10.1016/j.physbeh.2011.03.020",
language = "English",
volume = "103",
pages = "535--539",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys

AU - Coplan, Jeremy D.

AU - Abdallah, Chadi G.

AU - Mathew, Sanjay J.

AU - Shungu, Dikoma C.

AU - Mao, Xiangling

AU - Smith, Eric L P

AU - Kaufman, Daniel

AU - Gorman, Jack M.

AU - Owens, Michael J.

AU - Nemeroff, Charles

AU - Banerji, Mary Ann

AU - Rosenblum, Leonard A.

AU - Kral, John G.

PY - 2011/7/6

Y1 - 2011/7/6

N2 - Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls. Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI; sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators. Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator. Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity.

AB - Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls. Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI; sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators. Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator. Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity.

KW - Corticotropin releasing factor

KW - Food insecurity

KW - Hippocampus

KW - Metabolic syndrome

KW - Obesity

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=79955725764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955725764&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2011.03.020

DO - 10.1016/j.physbeh.2011.03.020

M3 - Article

C2 - 21459102

AN - SCOPUS:79955725764

VL - 103

SP - 535

EP - 539

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -