Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys

Jeremy D. Coplan, Chadi G. Abdallah, Sanjay J. Mathew, Dikoma C. Shungu, Xiangling Mao, Eric L.P. Smith, Daniel Kaufman, Jack M. Gorman, Michael J. Owens, Charles B. Nemeroff, Mary Ann Banerji, Leonard A. Rosenblum, John G. Kral

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls. Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI; sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators. Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator. Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalPhysiology AND Behavior
Volume103
Issue number5
DOIs
StatePublished - Jul 6 2011

Keywords

  • Corticotropin releasing factor
  • Food insecurity
  • Hippocampus
  • Metabolic syndrome
  • Obesity
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology

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    Coplan, J. D., Abdallah, C. G., Mathew, S. J., Shungu, D. C., Mao, X., Smith, E. L. P., Kaufman, D., Gorman, J. M., Owens, M. J., Nemeroff, C. B., Banerji, M. A., Rosenblum, L. A., & Kral, J. G. (2011). Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. Physiology AND Behavior, 103(5), 535-539. https://doi.org/10.1016/j.physbeh.2011.03.020