Metabolic Indicators of Islet Graft Dysfunction

Raquel N. Faradji, Kathy Monroy, Misha Denham, Camillo Ricordi, Rodolfo Alejandro

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Assessing β-cell mass and function is of great importance in the islet transplant setting but it has been challenging. Although achieving insulin independence has been one of the most important end points of islet transplantation (IT), it is critical that it is associated with good glycemic control. Numerous tests have been suggested for the assessment of graft dysfunction. Unfortunately, there are no effective indicators for the early detection of graft dysfunction in IT patients.1 In this chapter we discuss the different metabolic approaches for the assessment of graft dysfunction, nevertheless it is important to recognize that there is no consensus on which test is best to study β-cell mass and function in patients after IT. The early detection of graft dysfunction could facilitate the identification of underlying causes and guide in the management of transplanted patients, especially if appropriate anti-rejection therapies become available.

Original languageEnglish (US)
Title of host publicationChronic Allograft Failure
Subtitle of host publicationNatural History, Pathogenesis, Diagnosis and Management
PublisherCRC Press
Pages243-246
Number of pages4
ISBN (Electronic)9781498712729
ISBN (Print)9781587061530
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Faradji, R. N., Monroy, K., Denham, M., Ricordi, C., & Alejandro, R. (2008). Metabolic Indicators of Islet Graft Dysfunction. In Chronic Allograft Failure: Natural History, Pathogenesis, Diagnosis and Management (pp. 243-246). CRC Press. https://doi.org/10.1201/9781498712729-39