Abstract
Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate–glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores.
| Original language | English (US) |
|---|---|
| Journal | Multiple Sclerosis Journal |
| DOIs | |
| State | Accepted/In press - Oct 1 2017 |
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Keywords
- Na-MRI
- demyelination
- MRSI
- multiple sclerosis
- neurodegeneration
- stepwise regression
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Metabolic counterparts of sodium accumulation in multiple sclerosis : A whole brain 23Na-MRI and fast 1H-MRSI study. / Donadieu, Maxime; Le Fur, Yann; Maarouf, Adil; Gherib, Soraya; Ridley, Ben; Pini, Lauriane; Rapacchi, Stanislas; Confort-Gouny, Sylviane; Guye, Maxime; Schad, Lothar R.; Maudsley, Andrew A; Pelletier, Jean; Audoin, Bertrand; Zaaraoui, Wafaa; Ranjeva, Jean Philippe.
In: Multiple Sclerosis Journal, 01.10.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic counterparts of sodium accumulation in multiple sclerosis
T2 - A whole brain 23Na-MRI and fast 1H-MRSI study
AU - Donadieu, Maxime
AU - Le Fur, Yann
AU - Maarouf, Adil
AU - Gherib, Soraya
AU - Ridley, Ben
AU - Pini, Lauriane
AU - Rapacchi, Stanislas
AU - Confort-Gouny, Sylviane
AU - Guye, Maxime
AU - Schad, Lothar R.
AU - Maudsley, Andrew A
AU - Pelletier, Jean
AU - Audoin, Bertrand
AU - Zaaraoui, Wafaa
AU - Ranjeva, Jean Philippe
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate–glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores.
AB - Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate–glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores.
KW - Na-MRI
KW - demyelination
KW - MRSI
KW - multiple sclerosis
KW - neurodegeneration
KW - stepwise regression
UR - http://www.scopus.com/inward/record.url?scp=85041345444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041345444&partnerID=8YFLogxK
U2 - 10.1177/1352458517736146
DO - 10.1177/1352458517736146
M3 - Article
AN - SCOPUS:85041345444
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
ER -