Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma c-peptide levels) and circulating insulin antibodies

B. Gonen, J. Goldman, D. Baldwin, R. B. Goldberg, W. G. Ryan, P. M. Blix, D. Schanzlin, K. J. Fritz, A. H. Rubenstein

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The authors measured circulating hemoglobin A 1 (HbA 1) and fasting plasma C-peptide concentrations in 100 diabetic patients. Pancreatic insulin reserve showed a negative correlation with HbA 1 concentrations in nonobese, insulin-treated patients but not in obese patients, whether they were treated with insulin, oral agent, or diet alone. Patients with fasting C-peptide concentrations above 0.1 pmol/ml had significantly better metabolic control than did those with lower values. Anti-insulin antibodies were measured in 37 patients. There was no correlation between metabolic control and the affinity constants or binding capacities of these antibodies.

Original languageEnglish (US)
Pages (from-to)749-753
Number of pages5
JournalUnknown Journal
Volume28
Issue number8
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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