Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma c-peptide levels) and circulating insulin antibodies

B. Gonen, J. Goldman, D. Baldwin, Ronald B Goldberg, W. G. Ryan, P. M. Blix, D. Schanzlin, K. J. Fritz, A. H. Rubenstein

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The authors measured circulating hemoglobin A 1 (HbA 1) and fasting plasma C-peptide concentrations in 100 diabetic patients. Pancreatic insulin reserve showed a negative correlation with HbA 1 concentrations in nonobese, insulin-treated patients but not in obese patients, whether they were treated with insulin, oral agent, or diet alone. Patients with fasting C-peptide concentrations above 0.1 pmol/ml had significantly better metabolic control than did those with lower values. Anti-insulin antibodies were measured in 37 patients. There was no correlation between metabolic control and the affinity constants or binding capacities of these antibodies.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalDiabetes
Volume28
Issue number8
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Insulin Antibodies
Insulin
Peptides
C-Peptide
Glycosylated Hemoglobin A
Fasting
Anti-Idiotypic Antibodies
Diet
Antibodies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma c-peptide levels) and circulating insulin antibodies. / Gonen, B.; Goldman, J.; Baldwin, D.; Goldberg, Ronald B; Ryan, W. G.; Blix, P. M.; Schanzlin, D.; Fritz, K. J.; Rubenstein, A. H.

In: Diabetes, Vol. 28, No. 8, 01.12.1979, p. 749-753.

Research output: Contribution to journalArticle

Gonen, B, Goldman, J, Baldwin, D, Goldberg, RB, Ryan, WG, Blix, PM, Schanzlin, D, Fritz, KJ & Rubenstein, AH 1979, 'Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma c-peptide levels) and circulating insulin antibodies', Diabetes, vol. 28, no. 8, pp. 749-753.
Gonen, B. ; Goldman, J. ; Baldwin, D. ; Goldberg, Ronald B ; Ryan, W. G. ; Blix, P. M. ; Schanzlin, D. ; Fritz, K. J. ; Rubenstein, A. H. / Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma c-peptide levels) and circulating insulin antibodies. In: Diabetes. 1979 ; Vol. 28, No. 8. pp. 749-753.
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