Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: Relationship to disease onset and MRI findings

S. Pascal, L. Resnick, W. W. Barker, D. Loewenstein, F. Yoshii, J. Y. Chang, T. Boothe, Jerome J. Sheldon, Ranjan Duara

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Fifteen male homosexual subjects (mean age 31.6 ± 7.2 yr) who were asymptomatic, but HIV-1 seropositive (HIV+) were compared to 15 male age-matched HIV-1 seronegative (HIV-) subjects using resting PET/FDG studies and MR scans. Mean cerebral metabolic rates for glucose (mg/100 g/min) in the HIV+ and HIV- subjects were 7.7 ± 1.7 and 7.0 ± 2.1, (p = 0.44), respectively. An index of regional metabolic asymmetry for the whole brain was 5.8% ± 3.2% in the HIV+ and 2.7% ± 2.3% in the HIV- (p = 0.002), and the difference was most prominent in the prefrontal area. Significant asymmetries were found in 10/15 HIV+ subjects, primarily in prefrontal (7/15) and premotor (4/15) regions. MRI scans showed no abnormalities on clinical or quantitative evaluation in HIV+ subjects. Upon follow-up of HIV+ subjects over 18-40 mo, seven became symptomatic, of which two died. There was no relationship between the presence of PET scan abnormalities and earlier onset of symptomatic disease.

Original languageEnglish (US)
Pages (from-to)1725-1729
Number of pages5
JournalJournal of Nuclear Medicine
Volume32
Issue number9
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Pascal, S., Resnick, L., Barker, W. W., Loewenstein, D., Yoshii, F., Chang, J. Y., Boothe, T., Sheldon, J. J., & Duara, R. (1991). Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: Relationship to disease onset and MRI findings. Journal of Nuclear Medicine, 32(9), 1725-1729.