Abstract
Fifteen male homosexual subjects (mean age 31.6 ± 7.2 yr) who were asymptomatic, but HIV-1 seropositive (HIV+) were compared to 15 male age-matched HIV-1 seronegative (HIV-) subjects using resting PET/FDG studies and MR scans. Mean cerebral metabolic rates for glucose (mg/100 g/min) in the HIV+ and HIV- subjects were 7.7 ± 1.7 and 7.0 ± 2.1, (p = 0.44), respectively. An index of regional metabolic asymmetry for the whole brain was 5.8% ± 3.2% in the HIV+ and 2.7% ± 2.3% in the HIV- (p = 0.002), and the difference was most prominent in the prefrontal area. Significant asymmetries were found in 10/15 HIV+ subjects, primarily in prefrontal (7/15) and premotor (4/15) regions. MRI scans showed no abnormalities on clinical or quantitative evaluation in HIV+ subjects. Upon follow-up of HIV+ subjects over 18-40 mo, seven became symptomatic, of which two died. There was no relationship between the presence of PET scan abnormalities and earlier onset of symptomatic disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1725-1729 |
| Number of pages | 5 |
| Journal | Journal of Nuclear Medicine |
| Volume | 32 |
| Issue number | 9 |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects : Relationship to disease onset and MRI findings. / Pascal, S.; Resnick, L.; Barker, W. W.; Loewenstein, David; Yoshii, F.; Chang, J. Y.; Boothe, T.; Sheldon, J.; Duara, R.
In: Journal of Nuclear Medicine, Vol. 32, No. 9, 01.01.1991, p. 1725-1729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects
T2 - Relationship to disease onset and MRI findings
AU - Pascal, S.
AU - Resnick, L.
AU - Barker, W. W.
AU - Loewenstein, David
AU - Yoshii, F.
AU - Chang, J. Y.
AU - Boothe, T.
AU - Sheldon, J.
AU - Duara, R.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Fifteen male homosexual subjects (mean age 31.6 ± 7.2 yr) who were asymptomatic, but HIV-1 seropositive (HIV+) were compared to 15 male age-matched HIV-1 seronegative (HIV-) subjects using resting PET/FDG studies and MR scans. Mean cerebral metabolic rates for glucose (mg/100 g/min) in the HIV+ and HIV- subjects were 7.7 ± 1.7 and 7.0 ± 2.1, (p = 0.44), respectively. An index of regional metabolic asymmetry for the whole brain was 5.8% ± 3.2% in the HIV+ and 2.7% ± 2.3% in the HIV- (p = 0.002), and the difference was most prominent in the prefrontal area. Significant asymmetries were found in 10/15 HIV+ subjects, primarily in prefrontal (7/15) and premotor (4/15) regions. MRI scans showed no abnormalities on clinical or quantitative evaluation in HIV+ subjects. Upon follow-up of HIV+ subjects over 18-40 mo, seven became symptomatic, of which two died. There was no relationship between the presence of PET scan abnormalities and earlier onset of symptomatic disease.
AB - Fifteen male homosexual subjects (mean age 31.6 ± 7.2 yr) who were asymptomatic, but HIV-1 seropositive (HIV+) were compared to 15 male age-matched HIV-1 seronegative (HIV-) subjects using resting PET/FDG studies and MR scans. Mean cerebral metabolic rates for glucose (mg/100 g/min) in the HIV+ and HIV- subjects were 7.7 ± 1.7 and 7.0 ± 2.1, (p = 0.44), respectively. An index of regional metabolic asymmetry for the whole brain was 5.8% ± 3.2% in the HIV+ and 2.7% ± 2.3% in the HIV- (p = 0.002), and the difference was most prominent in the prefrontal area. Significant asymmetries were found in 10/15 HIV+ subjects, primarily in prefrontal (7/15) and premotor (4/15) regions. MRI scans showed no abnormalities on clinical or quantitative evaluation in HIV+ subjects. Upon follow-up of HIV+ subjects over 18-40 mo, seven became symptomatic, of which two died. There was no relationship between the presence of PET scan abnormalities and earlier onset of symptomatic disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025875626&partnerID=8YFLogxK
M3 - Article
C2 - 1880574
AN - SCOPUS:0025875626
VL - 32
SP - 1725
EP - 1729
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 9
ER -