Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: Relationship to disease onset and MRI findings

S. Pascal, L. Resnick, W. W. Barker, David Loewenstein, F. Yoshii, J. Y. Chang, T. Boothe, J. Sheldon, R. Duara

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Abstract

Fifteen male homosexual subjects (mean age 31.6 ± 7.2 yr) who were asymptomatic, but HIV-1 seropositive (HIV+) were compared to 15 male age-matched HIV-1 seronegative (HIV-) subjects using resting PET/FDG studies and MR scans. Mean cerebral metabolic rates for glucose (mg/100 g/min) in the HIV+ and HIV- subjects were 7.7 ± 1.7 and 7.0 ± 2.1, (p = 0.44), respectively. An index of regional metabolic asymmetry for the whole brain was 5.8% ± 3.2% in the HIV+ and 2.7% ± 2.3% in the HIV- (p = 0.002), and the difference was most prominent in the prefrontal area. Significant asymmetries were found in 10/15 HIV+ subjects, primarily in prefrontal (7/15) and premotor (4/15) regions. MRI scans showed no abnormalities on clinical or quantitative evaluation in HIV+ subjects. Upon follow-up of HIV+ subjects over 18-40 mo, seven became symptomatic, of which two died. There was no relationship between the presence of PET scan abnormalities and earlier onset of symptomatic disease.

Original languageEnglish
Pages (from-to)1725-1729
Number of pages5
JournalJournal of Nuclear Medicine
Volume32
Issue number9
StatePublished - Jan 1 1991
Externally publishedYes

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HIV-1
HIV
Positron-Emission Tomography
Magnetic Resonance Imaging
Glucose
Brain

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Pascal, S., Resnick, L., Barker, W. W., Loewenstein, D., Yoshii, F., Chang, J. Y., ... Duara, R. (1991). Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: Relationship to disease onset and MRI findings. Journal of Nuclear Medicine, 32(9), 1725-1729.

Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects : Relationship to disease onset and MRI findings. / Pascal, S.; Resnick, L.; Barker, W. W.; Loewenstein, David; Yoshii, F.; Chang, J. Y.; Boothe, T.; Sheldon, J.; Duara, R.

In: Journal of Nuclear Medicine, Vol. 32, No. 9, 01.01.1991, p. 1725-1729.

Research output: Contribution to journalArticle

Pascal, S, Resnick, L, Barker, WW, Loewenstein, D, Yoshii, F, Chang, JY, Boothe, T, Sheldon, J & Duara, R 1991, 'Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: Relationship to disease onset and MRI findings', Journal of Nuclear Medicine, vol. 32, no. 9, pp. 1725-1729.
Pascal, S. ; Resnick, L. ; Barker, W. W. ; Loewenstein, David ; Yoshii, F. ; Chang, J. Y. ; Boothe, T. ; Sheldon, J. ; Duara, R. / Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects : Relationship to disease onset and MRI findings. In: Journal of Nuclear Medicine. 1991 ; Vol. 32, No. 9. pp. 1725-1729.
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