Metabolic and respiratory effects of flow-resistive loading in preterm infants

Shahnaz Duara, G. Silva Neto, T. Gerhardt, C. Suguiohara, Eduardo Bancalari

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Oxygen consumption (V̇O2) was measured during hypoventilation induced by moderate-sized flow-resistive loading in 12 preterm infants, and the results were compared with those obtained under basal conditions immediately before and after the loaded run, each of which lasted for 7-10 min. Loading was performed with a continuous flow-resistive load (inspiratory and expiratory), which was approximately threefold greater in magnitude than the intrinsic resistance of preterm infants. V̇O2, minute ventilation (V̇E), transcutaneous oxygen tension (Ptc(O2)), and transcutaneous carbon dioxide tension (Ptc(CO2)) were continuously monitored. Results revealed that V̇E decreased significantly with loading, from 336 ± 103 to 231 ± 58 (SD) ml · min-1 · kg-1 (P < 0.001), while returning to basal levels of 342 ± 59 ml · min-1 · kg-1 after discontinuation of the load. V̇O2 decreased from 7.2 ± 1.2 to 5.9 ± 0.9 ml · min-1 · kg-1 with loading (P < 0.001) and returned to 7.2 ± 1.2 ml · min-1 · kg-1 at the second basal measurement. Ptc(O2) remained unchanged with loading, and Ptc(CO2) only increase from 39 ± 8 to 41 ± 9 Torr (P < 0.05) with loading, while returning to 40 ± 9 Torr at the second basal measurement. Results indicate a decrease in the metabolic rate and ventilation with loading, with relatively little increase in Ptc(CO2). These data can explain prior observations that minimal disturbances in oxygen and carbon dioxide tensions occur with hypoventilation during flow-resistive loading in neonates, although the precise mechanism for this reduction remains to be determined.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalJournal of Applied Physiology
Volume70
Issue number2
StatePublished - Jan 1 1991

Fingerprint

Premature Infants
Ventilation
Hypoventilation
Carbon Dioxide
Oxygen
Oxygen Consumption
Newborn Infant

Keywords

  • hypoventilation
  • minute ventilation
  • oxygen consumption

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Metabolic and respiratory effects of flow-resistive loading in preterm infants. / Duara, Shahnaz; Silva Neto, G.; Gerhardt, T.; Suguiohara, C.; Bancalari, Eduardo.

In: Journal of Applied Physiology, Vol. 70, No. 2, 01.01.1991, p. 895-899.

Research output: Contribution to journalArticle

Duara, Shahnaz ; Silva Neto, G. ; Gerhardt, T. ; Suguiohara, C. ; Bancalari, Eduardo. / Metabolic and respiratory effects of flow-resistive loading in preterm infants. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 2. pp. 895-899.
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