Metabolic acidosis with extreme elevation of anion gap: Case report and literature review

James R. Oster, Irwin Singer, Gabriel Contreras, H. I. Ahmad, Cristovao F. Vieira

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A patient with severe metabolic acidosis and an extremely elevated (57 mEq/L) serum anion gap (AG) is described, and the multiple factors that produced the patient's complex abnormalities are discussed in detail. These include renal failure, rhabdomyolysis, marked hyperphostemia, hemoconcentration, and an unidentified organic metabolic acidosis. A review of the literature indicates that the common thread observed in almost each instance of profoundly elevated AG values is a multifactorial pathogenesis that usually includes renal insufficiency, associated with a proven or likely cause of organic metabolic acidosis, or with exogenous phosphate intoxication.

Original languageEnglish
Pages (from-to)38-49
Number of pages12
JournalAmerican Journal of the Medical Sciences
Volume317
Issue number1
StatePublished - Jan 1 1999

Fingerprint

Acid-Base Equilibrium
Acidosis
Renal Insufficiency
Rhabdomyolysis
Phosphates
Serum

Keywords

  • Anion gap
  • Hyperphosphatemia
  • Metabolic acidosis
  • Renal failure
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Metabolic acidosis with extreme elevation of anion gap : Case report and literature review. / Oster, James R.; Singer, Irwin; Contreras, Gabriel; Ahmad, H. I.; Vieira, Cristovao F.

In: American Journal of the Medical Sciences, Vol. 317, No. 1, 01.01.1999, p. 38-49.

Research output: Contribution to journalArticle

Oster, James R. ; Singer, Irwin ; Contreras, Gabriel ; Ahmad, H. I. ; Vieira, Cristovao F. / Metabolic acidosis with extreme elevation of anion gap : Case report and literature review. In: American Journal of the Medical Sciences. 1999 ; Vol. 317, No. 1. pp. 38-49.
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