Meta-analysis: The impact of nutritional status on the immune response to hepatitis B virus vaccine in chronic kidney disease

Fabrizio Fabrizi, Michel Jadoul, Vivek Dixit, Piergiorgio Messa, Paul Martin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background Patients with chronic kidney disease (CKD) typically show a diminished immune response to hepatitis B virus (HBV) vaccine compared with individuals with intact kidney function. A number of inherited or acquired factors have been implicated in this suboptimal response. Patients with chronic kidney disease frequently have a compromised nutritional status; however, the impact of malnutrition on the immune response to hepatitis B virus vaccine in chronic kidney disease patients remains unclear. Aim To evaluate the infuence of nutrition status on the immune response to HBV vaccine in CKD population by performing a systematic review of the literature with a meta-analysis of clinical studies. Methods Study-specific relative risks were weighted by the inverse of their variance to obtain fixed- and randomeffects pooled estimates of impaired vaccine response across the published studies. The risk of poor serological response to HBV vaccine in chronic kidney disease population according to nutritional parameters was regarded as the most reliable outcome end-point. Only studies performing multivariate analysis in order to make adjustments for potential confounders were included. Results We identified seven studies (15,172 unique patients with CKD). The serum protection rate after a full course of recombinant or plasma-derived vaccine towards HBV ranged between 40 and 86%. Aggregation of study results showed an independent and adverse effect of poor nutrition status, as mostly detected by serum albumin levels, on the protection rate after HBV vaccine course; the summary estimate for adjusted RR was 1.50 with a 95% confidence interval (CI) of 1.02, 2.21; R i = 0.01 (randomeffects model). The P value for study heterogeneity was significant (Q = 0.0001). In the subgroup of patients who received HBV recombinant vaccine, the relative risk of impaired serological response after HBV vaccination was 1.63 (95% CI, 1.08, 2.45), R i = 0.90, Q = 0.00001, with poor nutritional parameters at baseline. Conclusions An increased risk exists of impaired serologic response to HBV vaccine response among chronic kidney disease patients having poor nutrition status. Additional studies are needed to understand better the mechanisms underlying the relationship between nutritional status and serological response to HBV vaccine among patients with CKD.

Original languageEnglish
Pages (from-to)1366-1372
Number of pages7
JournalDigestive Diseases and Sciences
Volume57
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Hepatitis B Vaccines
Nutritional Status
Chronic Renal Insufficiency
Hepatitis B virus
Meta-Analysis
Vaccines
Confidence Intervals
Synthetic Vaccines
Serum Albumin
Malnutrition
Population
Vaccination
Multivariate Analysis
Kidney

Keywords

  • Chronic kidney disease
  • Hepatitis B virus
  • Meta-analysis
  • Nutritional status
  • Recombinant vaccine

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Meta-analysis : The impact of nutritional status on the immune response to hepatitis B virus vaccine in chronic kidney disease. / Fabrizi, Fabrizio; Jadoul, Michel; Dixit, Vivek; Messa, Piergiorgio; Martin, Paul.

In: Digestive Diseases and Sciences, Vol. 57, No. 5, 01.05.2012, p. 1366-1372.

Research output: Contribution to journalArticle

Fabrizi, Fabrizio ; Jadoul, Michel ; Dixit, Vivek ; Messa, Piergiorgio ; Martin, Paul. / Meta-analysis : The impact of nutritional status on the immune response to hepatitis B virus vaccine in chronic kidney disease. In: Digestive Diseases and Sciences. 2012 ; Vol. 57, No. 5. pp. 1366-1372.
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abstract = "Background Patients with chronic kidney disease (CKD) typically show a diminished immune response to hepatitis B virus (HBV) vaccine compared with individuals with intact kidney function. A number of inherited or acquired factors have been implicated in this suboptimal response. Patients with chronic kidney disease frequently have a compromised nutritional status; however, the impact of malnutrition on the immune response to hepatitis B virus vaccine in chronic kidney disease patients remains unclear. Aim To evaluate the infuence of nutrition status on the immune response to HBV vaccine in CKD population by performing a systematic review of the literature with a meta-analysis of clinical studies. Methods Study-specific relative risks were weighted by the inverse of their variance to obtain fixed- and randomeffects pooled estimates of impaired vaccine response across the published studies. The risk of poor serological response to HBV vaccine in chronic kidney disease population according to nutritional parameters was regarded as the most reliable outcome end-point. Only studies performing multivariate analysis in order to make adjustments for potential confounders were included. Results We identified seven studies (15,172 unique patients with CKD). The serum protection rate after a full course of recombinant or plasma-derived vaccine towards HBV ranged between 40 and 86{\%}. Aggregation of study results showed an independent and adverse effect of poor nutrition status, as mostly detected by serum albumin levels, on the protection rate after HBV vaccine course; the summary estimate for adjusted RR was 1.50 with a 95{\%} confidence interval (CI) of 1.02, 2.21; R i = 0.01 (randomeffects model). The P value for study heterogeneity was significant (Q = 0.0001). In the subgroup of patients who received HBV recombinant vaccine, the relative risk of impaired serological response after HBV vaccination was 1.63 (95{\%} CI, 1.08, 2.45), R i = 0.90, Q = 0.00001, with poor nutritional parameters at baseline. Conclusions An increased risk exists of impaired serologic response to HBV vaccine response among chronic kidney disease patients having poor nutrition status. Additional studies are needed to understand better the mechanisms underlying the relationship between nutritional status and serological response to HBV vaccine among patients with CKD.",
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T2 - The impact of nutritional status on the immune response to hepatitis B virus vaccine in chronic kidney disease

AU - Fabrizi, Fabrizio

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AU - Dixit, Vivek

AU - Messa, Piergiorgio

AU - Martin, Paul

PY - 2012/5/1

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N2 - Background Patients with chronic kidney disease (CKD) typically show a diminished immune response to hepatitis B virus (HBV) vaccine compared with individuals with intact kidney function. A number of inherited or acquired factors have been implicated in this suboptimal response. Patients with chronic kidney disease frequently have a compromised nutritional status; however, the impact of malnutrition on the immune response to hepatitis B virus vaccine in chronic kidney disease patients remains unclear. Aim To evaluate the infuence of nutrition status on the immune response to HBV vaccine in CKD population by performing a systematic review of the literature with a meta-analysis of clinical studies. Methods Study-specific relative risks were weighted by the inverse of their variance to obtain fixed- and randomeffects pooled estimates of impaired vaccine response across the published studies. The risk of poor serological response to HBV vaccine in chronic kidney disease population according to nutritional parameters was regarded as the most reliable outcome end-point. Only studies performing multivariate analysis in order to make adjustments for potential confounders were included. Results We identified seven studies (15,172 unique patients with CKD). The serum protection rate after a full course of recombinant or plasma-derived vaccine towards HBV ranged between 40 and 86%. Aggregation of study results showed an independent and adverse effect of poor nutrition status, as mostly detected by serum albumin levels, on the protection rate after HBV vaccine course; the summary estimate for adjusted RR was 1.50 with a 95% confidence interval (CI) of 1.02, 2.21; R i = 0.01 (randomeffects model). The P value for study heterogeneity was significant (Q = 0.0001). In the subgroup of patients who received HBV recombinant vaccine, the relative risk of impaired serological response after HBV vaccination was 1.63 (95% CI, 1.08, 2.45), R i = 0.90, Q = 0.00001, with poor nutritional parameters at baseline. Conclusions An increased risk exists of impaired serologic response to HBV vaccine response among chronic kidney disease patients having poor nutrition status. Additional studies are needed to understand better the mechanisms underlying the relationship between nutritional status and serological response to HBV vaccine among patients with CKD.

AB - Background Patients with chronic kidney disease (CKD) typically show a diminished immune response to hepatitis B virus (HBV) vaccine compared with individuals with intact kidney function. A number of inherited or acquired factors have been implicated in this suboptimal response. Patients with chronic kidney disease frequently have a compromised nutritional status; however, the impact of malnutrition on the immune response to hepatitis B virus vaccine in chronic kidney disease patients remains unclear. Aim To evaluate the infuence of nutrition status on the immune response to HBV vaccine in CKD population by performing a systematic review of the literature with a meta-analysis of clinical studies. Methods Study-specific relative risks were weighted by the inverse of their variance to obtain fixed- and randomeffects pooled estimates of impaired vaccine response across the published studies. The risk of poor serological response to HBV vaccine in chronic kidney disease population according to nutritional parameters was regarded as the most reliable outcome end-point. Only studies performing multivariate analysis in order to make adjustments for potential confounders were included. Results We identified seven studies (15,172 unique patients with CKD). The serum protection rate after a full course of recombinant or plasma-derived vaccine towards HBV ranged between 40 and 86%. Aggregation of study results showed an independent and adverse effect of poor nutrition status, as mostly detected by serum albumin levels, on the protection rate after HBV vaccine course; the summary estimate for adjusted RR was 1.50 with a 95% confidence interval (CI) of 1.02, 2.21; R i = 0.01 (randomeffects model). The P value for study heterogeneity was significant (Q = 0.0001). In the subgroup of patients who received HBV recombinant vaccine, the relative risk of impaired serological response after HBV vaccination was 1.63 (95% CI, 1.08, 2.45), R i = 0.90, Q = 0.00001, with poor nutritional parameters at baseline. Conclusions An increased risk exists of impaired serologic response to HBV vaccine response among chronic kidney disease patients having poor nutrition status. Additional studies are needed to understand better the mechanisms underlying the relationship between nutritional status and serological response to HBV vaccine among patients with CKD.

KW - Chronic kidney disease

KW - Hepatitis B virus

KW - Meta-analysis

KW - Nutritional status

KW - Recombinant vaccine

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