Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too

Matt C. Danzi, Vance P. Lemmon

Research output: Contribution to journalComment/debate

Abstract

A necessary step toward complete functional recovery after spinal cord injury is the regeneration of axons. Axon regrowth after injury is prevented by a myriad of intrinsic and extrinsic factors. In this issue of The EMBO Journal, Huang et al () demonstrate that the cell adhesion molecule NB-3 (CNTN6) functions as a major brake on axon regrowth when it is activated by NB-3 from scar-forming cells at the injury site. Disruption of this NB-3 trans-cellular signaling led to impressive axon regrowth after spinal cord transection.

Original languageEnglish (US)
Pages (from-to)1721-1723
Number of pages3
JournalEMBO Journal
Volume35
Issue number16
DOIs
StatePublished - Aug 15 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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