Mesenchymal stem cells in solid organ transplantation (MiSOT) fourth meeting: Lessons learned from first clinical trials

Marcella Franquesa, Martin J. Hoogduijn, Marlies E. Reinders, Elke Eggenhofer, Anja U. Engela, Fane K. Mensah, Joan Torras, Antonello Pileggi, Cees Van Kooten, Bernard Mahon, Oliver Detry, Felix C. Popp, Volker Benseler, Federica Casiraghi, Christian Johnson, Janis Ancans, Barbara Fillenberg, Olga Delarosa, Josep M. Aran, Marieke Roemeling-VanrhijnJef Pinxteren, Norberto Perico, Eliana Gotti, Bruno Christ, James Reading, Martino Introna, Robert Deans, Murat Shagidulin, Ramon Farré, Alessandro Rambaldi, Albert Sanchez-Fueyo, Natasha Obermajer, Andrey Pulin, Frank J.M.F. Dor, Isabel Portero-Sanchez, Carla C. Baan, Ton J. Rabelink, Giuseppe Remuzzi, Michiel G.H. Betjes, Marc H. Dahlke, Josep M. Grinyó

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalTransplantation
Volume96
Issue number3
DOIs
StatePublished - Aug 15 2013
Externally publishedYes

Keywords

  • Immunomodulation
  • Mesenchymal stem cells
  • Position paper
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

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    Franquesa, M., Hoogduijn, M. J., Reinders, M. E., Eggenhofer, E., Engela, A. U., Mensah, F. K., Torras, J., Pileggi, A., Van Kooten, C., Mahon, B., Detry, O., Popp, F. C., Benseler, V., Casiraghi, F., Johnson, C., Ancans, J., Fillenberg, B., Delarosa, O., Aran, J. M., ... Grinyó, J. M. (2013). Mesenchymal stem cells in solid organ transplantation (MiSOT) fourth meeting: Lessons learned from first clinical trials. Transplantation, 96(3), 234-238. https://doi.org/10.1097/TP.0b013e318298f9fa