Mesenchymal stem cells in Lipogems, a reverse story: From clinical practice to basic science

Carlo Tremolada, Camillo Ricordi, Arnold I. Caplan, Carlo Ventura

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations


The idea that basic science should be the starting point for modern clinical approaches has been consolidated over the years, and emerged as the cornerstone of Molecular Medicine. Nevertheless, there is increasing concern over the low efficiency and inherent costs related to the translation of achievements from the bench to the bedside. These burdens are also perceived with respect to the effectiveness of translating basic discoveries in stem cell biology to the newly developing field of advanced cell therapy or Regenerative Medicine. As an alternative paradigm, past and recent history in Medical Science provides remarkable reverse stories in which clinical observations at the patient’s bedside have fed major advances in basic research which, in turn, led to consistent progression in clinical practice. Within this context, we discuss our recently developed method and device, which forms the core of a system (Lipogems) for processing of human adipose tissue solely with the aid of mild mechanical forces to yield a microfractured tissue product.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages14
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Adipose tissue
  • Adipose-derived stem cells
  • Chemical agents
  • Cryopreservation
  • Electromagnetic energy
  • Innovative device
  • Lipogems
  • Stromal vascular niche

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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