Mesenchymal stem cells in cardiology

Ian A. White, Cristina Sanina, Wayne E Balkan, Joshua Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Abstract

Cardiovascular disease (CVD) accounts for more deaths globally than any other single disease. There are on average 1.5 million episodes of myocardial infarction (heart attack) each year in the United States alone with roughly one-third resulting in death. There is therefore a major need for developing new and effective strategies to promote cardiac repair. Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. MSCs are potent mediators of cardiac repair and are therefore an attractive tool in the development of preclinical and clinical trials. MSCs are capable of secreting a large array of soluble factors, which have had demonstrated effects on pathogenic cardiac remolding, fibrosis, immune activation, and cardiac stem cell proliferation within the damaged heart. MSCs are also capable of differentiation into cardiomyocytes, endothelial cells, and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair remains the subject of active investigation.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages55-87
Number of pages33
Volume1416
DOIs
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1416
ISSN (Print)10643745

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Keywords

  • Cardiology
  • Cardiovascular Disease
  • Clinical trial
  • Mesenchymal stem cell
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

White, I. A., Sanina, C., Balkan, W. E., & Hare, J. (2016). Mesenchymal stem cells in cardiology. In Methods in Molecular Biology (Vol. 1416, pp. 55-87). (Methods in Molecular Biology; Vol. 1416). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3584-0_4