Mesenchymal Stem Cells for Periodontal Tissue Regeneration in Elderly Patients

Edgar Ledesma-Martínez, Víctor Manuel Mendoza-Núñez, Edelmiro Santiago-Osorio, Isabel Beerman, Joshua Hare

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Mesenchymal stem cell (MSC) grafting is a highly promising alternative strategy for periodontal regeneration in periodontitis, which is one of the primary causes of tooth loss in the elderly. However, aging progressively decreases the proliferative and differentiation potential of MSCs and diminishes their regenerative capacity, which represents a limiting factor for their endogenous use in elderly patients. Therefore, tissue regeneration therapy with MSCs in this age group may require a cellular source without the physiological limitations that MSCs exhibit in aging. In this sense, exogenous or allogeneic MSCs could have a better chance of success in regenerating periodontal tissue in elderly patients. This review examines and synthesizes recent data in support of the use of MSCs for periodontal regenerative therapy in patients. Additionally, we analyze the progress of the therapeutic use of exogenous MSCs in humans.

Original languageEnglish (US)
Pages (from-to)1351-1358
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number9
StatePublished - Aug 16 2019


  • Allogeneic
  • DPSC
  • Periodontal regenerative therapy

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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