Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy

Chad D. Markert; Anthony Atala; Jennifer K. Cann; George Christ; Mark Furth; Fabrisia Ambrosio; Martin K. Childers

doi:10.1016/j.pmrj.2009.02.013

Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy

Chad D. Markert, Anthony Atala, Jennifer K. Cann, George Christ, Mark Furth, Fabrisia Ambrosio, Martin K. Childers

Surgery

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Multipotent cells that can give rise to bone, cartilage, fat, connective tissue, and skeletal and cardiac muscle are termed mesenchymal stem cells. These cells were first identified in the bone marrow, distinct from blood-forming stem cells. Based on the embryologic derivation, availability, and various pro-regenerative characteristics, research exploring their use in cell therapy shows great promise for patients with degenerative muscle diseases and a number of other conditions. In this review, the authors explore the potential for mesenchymal stem cell therapy in the emerging field of regenerative medicine with a focus on treatment for Duchenne muscular dystrophy.

Original language	English (US)
Pages (from-to)	547-559
Number of pages	13
Journal	PM and R
Volume	1
Issue number	6
DOIs	https://doi.org/10.1016/j.pmrj.2009.02.013
State	Published - Jun 2009

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation
Neurology
Clinical Neurology

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title = "Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy",

abstract = "Multipotent cells that can give rise to bone, cartilage, fat, connective tissue, and skeletal and cardiac muscle are termed mesenchymal stem cells. These cells were first identified in the bone marrow, distinct from blood-forming stem cells. Based on the embryologic derivation, availability, and various pro-regenerative characteristics, research exploring their use in cell therapy shows great promise for patients with degenerative muscle diseases and a number of other conditions. In this review, the authors explore the potential for mesenchymal stem cell therapy in the emerging field of regenerative medicine with a focus on treatment for Duchenne muscular dystrophy.",

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AU - Cann, Jennifer K.

AU - Christ, George

AU - Furth, Mark

AU - Ambrosio, Fabrisia

AU - Childers, Martin K.

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AB - Multipotent cells that can give rise to bone, cartilage, fat, connective tissue, and skeletal and cardiac muscle are termed mesenchymal stem cells. These cells were first identified in the bone marrow, distinct from blood-forming stem cells. Based on the embryologic derivation, availability, and various pro-regenerative characteristics, research exploring their use in cell therapy shows great promise for patients with degenerative muscle diseases and a number of other conditions. In this review, the authors explore the potential for mesenchymal stem cell therapy in the emerging field of regenerative medicine with a focus on treatment for Duchenne muscular dystrophy.

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Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy

Abstract

ASJC Scopus subject areas

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