Mesenchymal stem cells: Characterization, properties and therapeutic potential

Anastasia Vedenko, Jennifer Barretta, Joshua M. Hare, Konstantinos E. Hatzistergos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal stem cells are one of the most widely studied cell types with promising applications in regenerative medicine, thanks to their abundant supply, ease of isolation, unique differentiation potential, immunosuppressive phenotype, and stimulation of endogenous repair mechanisms. Diverse sources of MSCs include embryonic and extraembryonic lineages and adult tissues, such as bone, fat, and cartilage, each intricately regulated by specific signaling pathways. MSCs are at the forefront of stem cell therapy, where they can be utilized as whole-cell, cell-free, or in combination with other cells to produce meaningful therapeutic outcomes for the treatment of cardiovascular, neurological, pulmonary, liver, and kidney disease. Here, we review the underlying biology and regenerative potential of MSCs.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages25-34
Number of pages10
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cell biology
  • Cell therapy
  • Developmental biology
  • Fibrosis
  • Immunomodulation
  • Mesenchymal stem cells
  • Mesenchymal stromal cells
  • Pericytes
  • Regenerative medicine
  • Stem cells
  • Tissue bioengineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Vedenko, A., Barretta, J., Hare, J. M., & Hatzistergos, K. E. (2019). Mesenchymal stem cells: Characterization, properties and therapeutic potential. In Encyclopedia of Tissue Engineering and Regenerative Medicine (Vol. 1-3, pp. 25-34). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.65435-1