Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Mathilde Roger, Anne Clavreul, Marie Claire Venier-Julienne, Catherine Passirani, Laurence Sindji, Paul C Schiller, Claudia Montero-Menei, Philippe Menei

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies represent great promise in glioma therapy as they protect therapeutic agent and allow its sustained release. However, new paradigms allowing tumor specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles (NPs). Knowing the tropism of mesenchymal stem cells (MSCs) for brain tumors, the aim of this study was to obtain the proof of concept that these cells can be used as NP delivery vehicles. Two types of NPs loaded with coumarin-6 were investigated: poly-lactic acid NPs (PLA-NPs) and lipid nanocapsules (LNCs). The results show that these NPs can be efficiently internalized into MSCs while cell viability and differentiation are not affected. Furthermore, these NP-loaded cells were able to migrate toward an experimental human glioma model. These data suggest that MSCs can serve as cellular carriers for NPs in brain tumors.

Original languageEnglish
Pages (from-to)8393-8401
Number of pages9
JournalBiomaterials
Volume31
Issue number32
DOIs
StatePublished - Nov 1 2010

Fingerprint

Stem cells
Mesenchymal Stromal Cells
Brain Neoplasms
Nanoparticles
Tumors
Brain
Glioma
Nanocapsules
Nanotechnology
Tropism
Chemotherapy
Therapeutics
Lactic acid
Radio
Surgery
Lipids
Cell Differentiation
Cell Survival
Cells
Neoplasms

Keywords

  • Cellular vehicle
  • Glioma
  • Mesenchymal stem cells
  • Nanoparticles

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Roger, M., Clavreul, A., Venier-Julienne, M. C., Passirani, C., Sindji, L., Schiller, P. C., ... Menei, P. (2010). Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. Biomaterials, 31(32), 8393-8401. https://doi.org/10.1016/j.biomaterials.2010.07.048

Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. / Roger, Mathilde; Clavreul, Anne; Venier-Julienne, Marie Claire; Passirani, Catherine; Sindji, Laurence; Schiller, Paul C; Montero-Menei, Claudia; Menei, Philippe.

In: Biomaterials, Vol. 31, No. 32, 01.11.2010, p. 8393-8401.

Research output: Contribution to journalArticle

Roger, M, Clavreul, A, Venier-Julienne, MC, Passirani, C, Sindji, L, Schiller, PC, Montero-Menei, C & Menei, P 2010, 'Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors', Biomaterials, vol. 31, no. 32, pp. 8393-8401. https://doi.org/10.1016/j.biomaterials.2010.07.048
Roger, Mathilde ; Clavreul, Anne ; Venier-Julienne, Marie Claire ; Passirani, Catherine ; Sindji, Laurence ; Schiller, Paul C ; Montero-Menei, Claudia ; Menei, Philippe. / Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. In: Biomaterials. 2010 ; Vol. 31, No. 32. pp. 8393-8401.
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