Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Mathilde Roger, Anne Clavreul, Marie Claire Venier-Julienne, Catherine Passirani, Laurence Sindji, Paul Schiller, Claudia Montero-Menei, Philippe Menei

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies represent great promise in glioma therapy as they protect therapeutic agent and allow its sustained release. However, new paradigms allowing tumor specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles (NPs). Knowing the tropism of mesenchymal stem cells (MSCs) for brain tumors, the aim of this study was to obtain the proof of concept that these cells can be used as NP delivery vehicles. Two types of NPs loaded with coumarin-6 were investigated: poly-lactic acid NPs (PLA-NPs) and lipid nanocapsules (LNCs). The results show that these NPs can be efficiently internalized into MSCs while cell viability and differentiation are not affected. Furthermore, these NP-loaded cells were able to migrate toward an experimental human glioma model. These data suggest that MSCs can serve as cellular carriers for NPs in brain tumors.

Original languageEnglish (US)
Pages (from-to)8393-8401
Number of pages9
JournalBiomaterials
Volume31
Issue number32
DOIs
StatePublished - Nov 1 2010

Keywords

  • Cellular vehicle
  • Glioma
  • Mesenchymal stem cells
  • Nanoparticles

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

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    Roger, M., Clavreul, A., Venier-Julienne, M. C., Passirani, C., Sindji, L., Schiller, P., Montero-Menei, C., & Menei, P. (2010). Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. Biomaterials, 31(32), 8393-8401. https://doi.org/10.1016/j.biomaterials.2010.07.048