Mesenchymal stem cell therapy for cardiac repair

Andrew J. Boyle, Ian K. McNiece, Joshua M. Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stem cell therapy for repair of damaged cardiac tissue is an attractive option to improve the health of the growing number of heart failure patients. Mesenchymal stem cells (MSCs) possess unique properties that may make them a better option for cardiac repair than other cell types. Unlike other adult stem cells, they appear to escape allorecognition by the immune system and they have immune-modulating properties, thus making it possible to consider them for use as an allogeneic cell therapy product. There is a large and growing body of preclinical and early clinical experience with MSC therapy that shows great promise in realizing the potential of stem cell therapy to effect repair of damaged cardiac tissue. This review discusses the mechanism of action of MSC therapy and summarizes the current literature in the field.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages65-84
Number of pages20
Volume660
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume660
ISSN (Print)10643745

Keywords

  • Cell therapy
  • Heart failure
  • Mesenchymal stem cell
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

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  • Cite this

    Boyle, A. J., McNiece, I. K., & Hare, J. M. (2010). Mesenchymal stem cell therapy for cardiac repair. In Methods in Molecular Biology (Vol. 660, pp. 65-84). (Methods in Molecular Biology; Vol. 660). https://doi.org/10.1007/978-1-60761-705-1-5