Mesenchymal stem cell therapy and delivery systems in nonhealing wounds.

Jonathan Brower, Sheila Blumberg, Emily Carroll, Irena Pastar, Harold Brem, Weiliam Chen

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The objective of the study was to inform wound care practitioners of mesenchymal stem cell application for nonhealing wounds. Recent advances in delivery systems are also discussed in order to highlight potential improvements toward clinical application of stem cell therapy for chronic wounds. MEDLINE and PubMed Central were searched for scientific studies regarding the use of mesenchymal stem cells and delivery systems in wound healing. Preclinical studies using stem cells as therapeutic modality for chronic wounds were selected for this review. Information on study design, sample size and characteristics, stem cell source, type of delivery systems, and rate and time of wound closure was abstracted. Application of mesenchymal stem cells improved wound healing in experimental and clinical settings. Advances in stem cell therapy and delivery vehicles offer promising alternatives to current limited therapeutic modalities for chronic wounds. Stem cell therapy has recently emerged as a promising therapeutic strategy for nonhealing wounds. Further research is needed to evaluate the relationship between the various delivery systems and stem cells in order to maximize their therapeutic effects. Development of novel delivery vehicles for stem cells can open new opportunities for more effective cell therapy of chronic wounds.

Original languageEnglish (US)
Pages (from-to)524-532; quiz 533-534
JournalAdvances in skin & wound care
Issue number11
StatePublished - Nov 2011
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology
  • Advanced and Specialized Nursing


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