Mesenchymal stem-cell potential in cartilage repair: An update

M. Mazor, E. Lespessailles, R. Coursier, R. Daniellou, T. M. Best, H. Toumi

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Articular cartilage damage and subsequent degeneration are a frequent occurrence in synovial joints. Treatment of these lesions is a challenge because this tissue is incapable of quality repair and/or regeneration to its native state. Non-operative treatments endeavour to control symptoms and include anti-inflammatory medications, viscosupplementation, bracing, orthotics and activity modification. Classical surgical techniques for articular cartilage lesions are frequently insufficient in restoring normal anatomy and function and in many cases, it has not been possible to achieve the desired results. Consequently, researchers and clinicians are focusing on alternative methods for cartilage preservation and repair. Recently, cell-based therapy has become a key focus of tissue engineering research to achieve functional replacement of articular cartilage. The present manuscript is a brief review of stem cells and their potential in the treatment of early OA (i.e. articular cartilage pathology) and recent progress in the field.

Original languageEnglish (US)
Pages (from-to)2340-2350
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume18
Issue number12
DOIs
StatePublished - Dec 1 2014

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Keywords

  • Cartilage
  • Growth factors
  • Mesenchymal stem cell
  • Osteoarthritis
  • Repair

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

Cite this

Mazor, M., Lespessailles, E., Coursier, R., Daniellou, R., Best, T. M., & Toumi, H. (2014). Mesenchymal stem-cell potential in cartilage repair: An update. Journal of Cellular and Molecular Medicine, 18(12), 2340-2350. https://doi.org/10.1111/jcmm.12378