Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats

Leopoldo Raij, S. Azar, W. Keane

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600 Citations (Scopus)

Abstract

Hypertension frequently accompanies chronic glomerulonephritis. Mesangial injury and glomerulosclerosis are common in glomerulonephritis and are often harbingers of progressive glomerular destruction. Thus, in a model of mesangial immune injury we studied the relationship between hypertension, mesangial injury, and glomerulosclerosis. We induced mesangial ferritin-antiferritin immune complex disease (FIC) in Dahl salt-sensitive (S) and salt-resistant (R) rats. S and R rats with FIC were fed chow containing 0.3% NaCl until 14 weeks of age and then switched to 8.0% NaCl chow until 28 weeks of age. Groups of control S and R rats (no FIC) were either fed 0.3% NaCl for 28 weeks or switched to 8.0% NaCl chow at 14 weeks of age. Blood pressure, serum creatinine, urinary protein, and glomerular injury (assessed by semiquantitative morphometric analysis) were determined at 14 and 28 weeks of age. (1) R rats with or without FIC did not develop hypertension; mesangial injury was minimal. (2) At 14 weeks of age, only S FIC rats developed hypertension, proteinuria, significant mesangial expansion and early glomerulosclerosis. (3) At 28 weeks of age, proteinuria, mesangial expansion, and glomerulosclerosis were significantly more severe in hypertensive S rats with FIC than in those without FIC. These studies show that despite a normal salt intake, mesangial injury hastened the onset of hypertension, but only in rats genetically predisposed to hypertension (S FIC at 14 weeks). High dietary salt further aggravated hypertension, which, in turn, magnified both mesangial injury and glomerulosclerosis. Clinically, the different rates of progression of human glomerulonephritis associated with hypertension may be in part dependent on similar mechanisms.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalKidney International
Volume26
Issue number2
StatePublished - Jan 1 1984
Externally publishedYes

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Immune Complex Diseases
Inbred Dahl Rats
Ferritins
Hypertension
Wounds and Injuries
Glomerulonephritis
Salts
Proteinuria
Creatinine
Blood Pressure
Control Groups

ASJC Scopus subject areas

  • Nephrology

Cite this

Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. / Raij, Leopoldo; Azar, S.; Keane, W.

In: Kidney International, Vol. 26, No. 2, 01.01.1984, p. 137-143.

Research output: Contribution to journalArticle

Raij, Leopoldo ; Azar, S. ; Keane, W. / Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. In: Kidney International. 1984 ; Vol. 26, No. 2. pp. 137-143.
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