Abstract
Background: Sex hormones and menstrual cycle effects on ST height have not yet been clearly identified. Methods: Twenty-two young, healthy women (aged 22-32 years) were included in this study. Twelve-lead ECGs were registered during menses, follicular and luteal phase of the menstrual cycle at baseline, and after double autonomic blockade (DAB). Chest leads V2-V4 and limb leads I and II were chosen for analysis. ST height was measured manually at J-Point and 40 ms after the J-Point, and values were corrected for QRS amplitude (J-Point/QRS, 40 ms/QRS). Repeated measure ANOVA was used to analyze differences in ST height among the three phases of the menstrual cycle. A P-value < 0.05 was considered as significant. Results: At baseline, ST height, QTc, and T wave amplitude were not significantly different among the three phases of the menstrual cycle. After double autonomic blockade, ST height at 40 ms, J-Point/QRS, and 40 ms/QRS was significantly higher during follicular versus luteal phase (0.152 ± 0.413 mm versus -0.007 ± 0.427 mm, P = 0.0059 at 40 ms; -0.001 ± 0.030 versus -0.015 ± 0.032, P = 0.0039 at J-Point/QRS; 0.013 ± 0.031 versus -0.004 ± 0.032, P = 0.0005 at 40 ms/QRS) as was the QTc. ST height differences at J-Point were not significantly different (-0.046 ± 0.395 mm follicular, -0.167 ± 0.448 mm luteal, and -0.083 ± 0.492 mm menses, P = 0.1014). Conclusion: ST height and QTc varied among the three phases of the menstrual cycle, predominantly after double autonomic blockade. Female sex hormones that vary throughout the menstrual cycle may modulate measures of repolarization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-126 |
| Number of pages | 6 |
| Journal | Annals of Noninvasive Electrocardiology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2004 |
| Externally published | Yes |
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Keywords
- Early repolarization
- Estrogen
- J-Point
- Menstrual cycle
- Sex hormone
- ST elevation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Menstrual cycle and ST height. / Endres, Susanne; Mayuga, Kenneth A.; De Cristofaro, Alessandro; Taneja, Taresh; Goldberger, Jeffrey; Kadish, Alan H.
In: Annals of Noninvasive Electrocardiology, Vol. 9, No. 2, 01.04.2004, p. 121-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Menstrual cycle and ST height
AU - Endres, Susanne
AU - Mayuga, Kenneth A.
AU - De Cristofaro, Alessandro
AU - Taneja, Taresh
AU - Goldberger, Jeffrey
AU - Kadish, Alan H.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Background: Sex hormones and menstrual cycle effects on ST height have not yet been clearly identified. Methods: Twenty-two young, healthy women (aged 22-32 years) were included in this study. Twelve-lead ECGs were registered during menses, follicular and luteal phase of the menstrual cycle at baseline, and after double autonomic blockade (DAB). Chest leads V2-V4 and limb leads I and II were chosen for analysis. ST height was measured manually at J-Point and 40 ms after the J-Point, and values were corrected for QRS amplitude (J-Point/QRS, 40 ms/QRS). Repeated measure ANOVA was used to analyze differences in ST height among the three phases of the menstrual cycle. A P-value < 0.05 was considered as significant. Results: At baseline, ST height, QTc, and T wave amplitude were not significantly different among the three phases of the menstrual cycle. After double autonomic blockade, ST height at 40 ms, J-Point/QRS, and 40 ms/QRS was significantly higher during follicular versus luteal phase (0.152 ± 0.413 mm versus -0.007 ± 0.427 mm, P = 0.0059 at 40 ms; -0.001 ± 0.030 versus -0.015 ± 0.032, P = 0.0039 at J-Point/QRS; 0.013 ± 0.031 versus -0.004 ± 0.032, P = 0.0005 at 40 ms/QRS) as was the QTc. ST height differences at J-Point were not significantly different (-0.046 ± 0.395 mm follicular, -0.167 ± 0.448 mm luteal, and -0.083 ± 0.492 mm menses, P = 0.1014). Conclusion: ST height and QTc varied among the three phases of the menstrual cycle, predominantly after double autonomic blockade. Female sex hormones that vary throughout the menstrual cycle may modulate measures of repolarization.
AB - Background: Sex hormones and menstrual cycle effects on ST height have not yet been clearly identified. Methods: Twenty-two young, healthy women (aged 22-32 years) were included in this study. Twelve-lead ECGs were registered during menses, follicular and luteal phase of the menstrual cycle at baseline, and after double autonomic blockade (DAB). Chest leads V2-V4 and limb leads I and II were chosen for analysis. ST height was measured manually at J-Point and 40 ms after the J-Point, and values were corrected for QRS amplitude (J-Point/QRS, 40 ms/QRS). Repeated measure ANOVA was used to analyze differences in ST height among the three phases of the menstrual cycle. A P-value < 0.05 was considered as significant. Results: At baseline, ST height, QTc, and T wave amplitude were not significantly different among the three phases of the menstrual cycle. After double autonomic blockade, ST height at 40 ms, J-Point/QRS, and 40 ms/QRS was significantly higher during follicular versus luteal phase (0.152 ± 0.413 mm versus -0.007 ± 0.427 mm, P = 0.0059 at 40 ms; -0.001 ± 0.030 versus -0.015 ± 0.032, P = 0.0039 at J-Point/QRS; 0.013 ± 0.031 versus -0.004 ± 0.032, P = 0.0005 at 40 ms/QRS) as was the QTc. ST height differences at J-Point were not significantly different (-0.046 ± 0.395 mm follicular, -0.167 ± 0.448 mm luteal, and -0.083 ± 0.492 mm menses, P = 0.1014). Conclusion: ST height and QTc varied among the three phases of the menstrual cycle, predominantly after double autonomic blockade. Female sex hormones that vary throughout the menstrual cycle may modulate measures of repolarization.
KW - Early repolarization
KW - Estrogen
KW - J-Point
KW - Menstrual cycle
KW - Sex hormone
KW - ST elevation
UR - http://www.scopus.com/inward/record.url?scp=2342496291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2342496291&partnerID=8YFLogxK
U2 - 10.1111/j.1542-474X.2004.92530.x
DO - 10.1111/j.1542-474X.2004.92530.x
M3 - Article
C2 - 15084208
AN - SCOPUS:2342496291
VL - 9
SP - 121
EP - 126
JO - Annals of Noninvasive Electrocardiology
JF - Annals of Noninvasive Electrocardiology
SN - 1082-720X
IS - 2
ER -