Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging

M. J. Berthiaume, Jean Pierre Raynauld, J. Martel-Pelletier, F. Labonté, G. Beaudoin, D. A. Bloch, D. Choquette, B. Haraoui, R. D. Altman, M. Hochberg, J. M. Meyer, G. A. Cline, J. P. Pelletier

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343 Scopus citations

Abstract

Background: The relation between knee meniscal structural damage and cartilage degradation is plausible but not yet clearly proven. Objectives: To quantitate the cartilage volume changes in knee osteoarthritis using magnetic resonance imaging (MRI), and determine whether meniscal alteration predicts cartilage volume loss over time. Methods: 32 patients meeting ACR criteria for symptomatic knee osteoarthritis were studied. MRI knee acquisitions were done every six months for two years. The cartilage volumes of different knee regions were measured. Three indices of structural change in the medial and lateral menisci were evaluated-degeneration, tear, and extrusion-using a semiquantitative scale. Results: 24 patients (75%) had mild to moderate or severe meniscal damage (tear or extrusion) at baseline. A highly significant difference in global cartilage volume loss was observed between severe medial meniscal tear and absence of tear (mean (SD), -10.1 (2.1)% v -5.1 (2.4)%, p = 0.002). An even greater difference was found between the medial meniscal changes and medial compartment cartilage volume loss (-14.3 (3.0)% in the presence of severe tear v -6.3 (2.7)% in the absence of tear; p<0.0001). Similarly, a major difference was found between the presence of a medial meniscal extrusion and loss of medial compartment cartilage volume (-15.4 (4.1)% in the presence of extrusion v -4.5 (1.7)% with no extrusion; p<0.001). Conclusions: Meniscal tear and extrusion appear to be associated with progression of symptomatic knee osteoarthritis.

Original languageEnglish (US)
Pages (from-to)556-563
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume64
Issue number4
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Berthiaume, M. J., Raynauld, J. P., Martel-Pelletier, J., Labonté, F., Beaudoin, G., Bloch, D. A., Choquette, D., Haraoui, B., Altman, R. D., Hochberg, M., Meyer, J. M., Cline, G. A., & Pelletier, J. P. (2005). Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging. Annals of the Rheumatic Diseases, 64(4), 556-563. https://doi.org/10.1136/ard.2004.023796