Meningioangiomatosis: Clinical, radiologic, and histopathologic correlation

Richard N. Aizpuru, Robert M. Quencer, Michael Norenberg, Nolan Altman, James Smirniotopoulos

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Meningioangiomatosis (MA) is a rare, benign, hamartomatous lesion of the leptomeninges; MA has been considered to be a forme fruste of neurofibromatosis. A review of pathology records for patients with MA who were seen between 1970 and 1989 at the authors' institutions revealed four patients (three male and one female; aged 2.5-21.0 years; mean, 10.8 years) with a history of seizures but without the stigmata or family history of neurofibromatosis. Three patients had undergone either computed tomographic (CT) or magnetic resonance (MR) imaging studies. All patients had undergone craniotomies to obtain tissue for pathologic analysis; a peripheral, leptomeningeal lesion was found in all four patients. At CT in two patients, the lesions were most consistent with calcification. At T2-weighted MR imaging in one patient, the lesion demonstrated a hyperintense periphery with associated edema of the white matter. Histopathologic examination demonstrated characteristic features of MA - cortical meningovascular fibroblastic proliferation and leptomeningeal calcification. The accurate diagnosis of MA is important since MA is a benign, surgically correctable cause of seizures.

Original languageEnglish (US)
Pages (from-to)819-821
Number of pages3
JournalRadiology
Volume179
Issue number3
DOIs
StatePublished - Jun 1991

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Keywords

  • Brain neoplasms, CT, 13.1211
  • Brain neoplasms, diagnosis, 13.366
  • Brain neoplasms, MR studies, 13.1214
  • Brain, calcification
  • Meninges, CT, 139.211
  • Meninges, MR studies, 139.1214
  • Meninges, neoplasms, 139.366
  • Meningioangiomatosis, 139.366

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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