Memory reconsolidation of cocaine-associated context requires nitric oxide signaling

Yossef Itzhak, Karen L. Anderson

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Recent studies suggest that long-term memory (LTM) is labile because retrieval of such memories may undergo a reconsolidation process which is vulnerable to disruption. Nitric oxide (NO) is a retrograde messenger involved in synaptic plasticity and LTM. In the present study the role of NO in reconsolidation of LTM of cocaine-associate context was investigated in wild type (WT) and neuronal nitric oxide synthase (nNOS) deficient mice (knockout; KO). LTM of cocaine-associated context was established in both WT and nNOS KO mice by conditioned place preference learning. Subsequently, the retrieval of place preference in WT mice was challenged by either saline or the selective nNOS inhibitor 7-nitroindazole, and retrieval of place preference in KO mice was challenged by either saline or the NO-donor molsidomine. Results suggest that in the absence of nNOS activity, particularly during the reconsolidation phase, LTM of cocaine-associated context is extinguished.

Original languageEnglish (US)
Pages (from-to)1002-1005
Number of pages4
JournalSynapse
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2007

Keywords

  • 7-nitroindazole
  • Cocaine
  • Conditioned place preference
  • Molsidomine
  • Reconsolidation
  • Reinstatement

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology
  • Advanced and Specialized Nursing

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