Abstract
Objective: We aimed to assess reliability and cross-sectional discriminative validity of the Memory Binding Test (MBT) to distinguish persons with amnestic cognitive impairment (aMCI) and dementia from cognitively normal elderly controls. Method: The MBT was administered to 20 participants with dementia, 31 with aMCI and 246 controls, who received the first administration of the MBT from May 2003 to December 2007, as a substudy of the community-based Einstein Aging Study (age range: 70+). The optimal index resulted from comparing the partial area under the receiver operating characteristic curves (ROC AUC) of four major MBT indices for specificities ≥0.70. Optimal cut-score of the optimal index was selected by maximizing the sum of sensitivity and specificity. Age and education effects were assessed using stratified cut-scores and adjusted logistic regression. Reliability was computed as intraclass correlation between scores at baseline and 1-year follow-up for participants who remained cognitively normal. Results: Total number of Items recalled in the Paired condition (TIP) was elected the optimal index. TIP cut-score was ≤22 for differentiating aMCI alone (sensitivity = 0.74, specificity = 0.73) and aMCI and dementia combined (sensitivity = 0.84, specificity = 0.73) from controls. It was ≤17 for differentiating dementia from aMCI and controls (sensitivity = 0.95, specificity = 0.87). Age and education adjustments did not materially improve discriminative validity. The reliability of TIP was 0.77. Conclusions: MBT achieved moderate to good reliability. TIP had superior cross-sectional discriminative validity than the other MBT indices. We recommend using the empirical cut-score of TIP ≤22 for discriminating aMCI and dementia and ≤17 for discriminating dementia alone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-39 |
| Number of pages | 11 |
| Journal | Archives of Clinical Neuropsychology |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- Alzheimer's disease
- Dementia
- Elderly/geriatrics/aging
- Learning and memory
- Mild cognitive impairment
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Memory binding test distinguishes amnestic mild cognitive impairment and dementia from cognitively normal elderly. / Buschke, Herman; Mowrey, Wenzhu B.; Ramratan, Wendy S.; Zimmerman, Molly E.; Loewenstein, David; Katz, Mindy J.; Lipton, Richard B.
In: Archives of Clinical Neuropsychology, Vol. 32, No. 1, 01.02.2017, p. 29-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Memory binding test distinguishes amnestic mild cognitive impairment and dementia from cognitively normal elderly
AU - Buschke, Herman
AU - Mowrey, Wenzhu B.
AU - Ramratan, Wendy S.
AU - Zimmerman, Molly E.
AU - Loewenstein, David
AU - Katz, Mindy J.
AU - Lipton, Richard B.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective: We aimed to assess reliability and cross-sectional discriminative validity of the Memory Binding Test (MBT) to distinguish persons with amnestic cognitive impairment (aMCI) and dementia from cognitively normal elderly controls. Method: The MBT was administered to 20 participants with dementia, 31 with aMCI and 246 controls, who received the first administration of the MBT from May 2003 to December 2007, as a substudy of the community-based Einstein Aging Study (age range: 70+). The optimal index resulted from comparing the partial area under the receiver operating characteristic curves (ROC AUC) of four major MBT indices for specificities ≥0.70. Optimal cut-score of the optimal index was selected by maximizing the sum of sensitivity and specificity. Age and education effects were assessed using stratified cut-scores and adjusted logistic regression. Reliability was computed as intraclass correlation between scores at baseline and 1-year follow-up for participants who remained cognitively normal. Results: Total number of Items recalled in the Paired condition (TIP) was elected the optimal index. TIP cut-score was ≤22 for differentiating aMCI alone (sensitivity = 0.74, specificity = 0.73) and aMCI and dementia combined (sensitivity = 0.84, specificity = 0.73) from controls. It was ≤17 for differentiating dementia from aMCI and controls (sensitivity = 0.95, specificity = 0.87). Age and education adjustments did not materially improve discriminative validity. The reliability of TIP was 0.77. Conclusions: MBT achieved moderate to good reliability. TIP had superior cross-sectional discriminative validity than the other MBT indices. We recommend using the empirical cut-score of TIP ≤22 for discriminating aMCI and dementia and ≤17 for discriminating dementia alone.
AB - Objective: We aimed to assess reliability and cross-sectional discriminative validity of the Memory Binding Test (MBT) to distinguish persons with amnestic cognitive impairment (aMCI) and dementia from cognitively normal elderly controls. Method: The MBT was administered to 20 participants with dementia, 31 with aMCI and 246 controls, who received the first administration of the MBT from May 2003 to December 2007, as a substudy of the community-based Einstein Aging Study (age range: 70+). The optimal index resulted from comparing the partial area under the receiver operating characteristic curves (ROC AUC) of four major MBT indices for specificities ≥0.70. Optimal cut-score of the optimal index was selected by maximizing the sum of sensitivity and specificity. Age and education effects were assessed using stratified cut-scores and adjusted logistic regression. Reliability was computed as intraclass correlation between scores at baseline and 1-year follow-up for participants who remained cognitively normal. Results: Total number of Items recalled in the Paired condition (TIP) was elected the optimal index. TIP cut-score was ≤22 for differentiating aMCI alone (sensitivity = 0.74, specificity = 0.73) and aMCI and dementia combined (sensitivity = 0.84, specificity = 0.73) from controls. It was ≤17 for differentiating dementia from aMCI and controls (sensitivity = 0.95, specificity = 0.87). Age and education adjustments did not materially improve discriminative validity. The reliability of TIP was 0.77. Conclusions: MBT achieved moderate to good reliability. TIP had superior cross-sectional discriminative validity than the other MBT indices. We recommend using the empirical cut-score of TIP ≤22 for discriminating aMCI and dementia and ≤17 for discriminating dementia alone.
KW - Alzheimer's disease
KW - Dementia
KW - Elderly/geriatrics/aging
KW - Learning and memory
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85012850937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012850937&partnerID=8YFLogxK
U2 - 10.1093/arclin/acw083
DO - 10.1093/arclin/acw083
M3 - Article
C2 - 27680087
AN - SCOPUS:85012850937
VL - 32
SP - 29
EP - 39
JO - Archives of Clinical Neuropsychology
JF - Archives of Clinical Neuropsychology
SN - 0887-6177
IS - 1
ER -